Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"β2AR"”.
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Modelling Β2Ar Regulation
<p>The β2 adrenergic receptor (β2AR) regulates smooth muscle relaxation in the vasculature and airways. Long- and Short-acting β-agonists (LABAs/SABAs) are widely used in treatment of chronic obstructive pulmonary disorder (COPD) and asthma. Despite their widespread clinical use we do not …
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Post-translational modifications regulate β2-Adrenoceptor signaling in cardiac myocytes
β2AR (β2 adrenoceptor) is a prototypical G-protein coupled receptor (GPCR) that plays an important role in cardiovascular and pulmonary physiology through activation of the classic Gs-adenylate cyclase-cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway. In the mammalian …
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Fusion Proteins as Selective Inducers of Constitutive Activity and Tools to Discriminate the Biased Signaling Profile of β2 Adrenoceptor Ligands
The β2AR is the prototypical G protein coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways. The best-established signaling pathways for the β2AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway. …
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AKAP12 Signalosome Regulates Cardiac β2-Adrenergic Receptor Signaling
… protein in mediating signaling downstream β2AR have been studied using overexpression and downregulation models. In vitro, on a molecular level, we showed that AKAP12 upregulation significantly reduced β2AR internalization and reduced intracellular cAMP levels downstream of the stimulated …
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Determining the Effects and Signaling Properties of β-Blockers in House Dust Mite-Driven Murine Models of Asthma
… corticosteroids (ICS) and β2-adrenoceptor (β2AR) agonists. However, chronic monotherapy with β2AR agonists has been associated with worsening of asthma control and an increase in asthma-related mortality. Previous studies in our laboratory discovered that agonist activation of the β2AR is …
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Getting at the Surface: A Promoter and Coding Sequence Characterization of an Odorant Receptor
… study between the β2-adrenergic receptor (β2AR), which traffics well to the plasma membrane and M71 OR, which does not. Using OP6 cells, wedetermined that the N-terminus and the first transmembrane domain of β2AR (β2AR NtàTM1) trafficked to the cell surface on its own, similarly to the full …
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Structure and function of V1b vasopressin receptor
… (bRho) and human β2 adrenergic receptor (β2AR) obtained by X-ray crystallography. This study aimed to identify amino acid residues which participate in ligand binding of the V1bR by site-directed mutagenesis with the aid of molecular models of vasopressin receptors based on the crystal …
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Aromatic Amino Acid Metabolome In The Human Gut Microbiota
… modulator (NAM) for β2-adrenergic receptor (β2AR). This work highlights several interesting metabolites specific to C. <em>difficile</em>, with potential biological roles that warrant further exploration.</p>
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An in vitro investigation of the molecular effects of aging and exercise signaling within human skeletal muscle cells
… signaling via the β-2 adrenergic receptor (β2AR) could rescue the dysregulated signaling resulting from aging. Human SKM myoblasts underwent an in vitro continued passaging protocol to represent aging in vivo. Formoterol (FORM), an exercise mimetic, was used to stimulate general exercise …
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Cryo-EM studies of class A GPCRs: the thyroid-stimulating hormone receptor and the β1-adrenoceptor
… β1AR antagonists have off-target effects on the β2AR that worsens the symptoms of respiratory diseases. Novel, highly β1AR-selective antagonists have been developed, but the structural basis for their selectivity is unknown. Using these ligands, a humanised turkey β1AR was expressed and purified …
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Identification of A Conserved Cluster In The Rh Domain of Grk Critical For Activation By Gpcrs
… phosphorylation of the β-2 Adrenergic Receptor (β2AR) in intact cells and phosphorylation of light-activated rhodopsin (Rho*) in vitro as compared to wild type (WT) GRK5 or 6. Based on these results, we designed peptide mimetics of GRK5 helix 9 both computationally and through chemical …
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Sympathy for the Microbiota: How Changes in Gut Microbial Composition Influence the Immune System and Basic Physiology by Way of the Sympathetic Nervous System
… was used to demonstrate that MM-specific Β2AR signaling is required to confer neuronal protection during the course of infection and prevent further pathogen-induced damage. Furthermore, translational profiling of iEAN led to the discovery that these neurons express a unique combination of …