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USING B-STRAND AND B-HAIRPIN PEPTIDOMIMETICS INDUCED BY CONSTRAINED AMINO ACIDS TO MODULATE THE AGGREGATION OF THE MICROTUBULE ASSOCIATED PROTEIN TAU: DESIGN, SYNTHESIS AND EVALUATION

DI LORENZO, DAVIDEUniversità degli Studi di Milano2023

… on Tau. Then, the employment of the non-natural β2,2-isoxazoline unit into a peptide sequence was used to stabilize two different secondary structures, either in β-hairpin or extended. These structures were confirmed through a combination of CD, IR, and NMR analyses in aqueous solvents. The …

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