Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"β1AR"”.
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Importance of cardiac reserve for evaluation and prediction of cardiac function and morbidity assessed by low-dose dobutamine stress echocardiography
… hypertensive), in mice (immunized against the β1AR) and in heart-transplanted patients. The cardiac reserve was assessed by low-dose dobutamine stress echocardiography. In both patient studies by dobutamine infusion until an increased baseline heart rate with ~20 bpm, in rats at doses of 10 …
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Cryo-EM studies of class A GPCRs: the thyroid-stimulating hormone receptor and the β1-adrenoceptor
… hormone receptor (TSHR) and the β1-adrenoceptor (β1AR) were studied. The TSHR is a class A GPCR that belongs to the family of glycoprotein hormone receptors. It carries a large extracellular domain (ECD) that binds to the endogenous ligand, the thyroid stimulating hormone (TSH). In autoimmune …
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Investigating the molecular signatures of β1-adrenergic receptor activation
… activation, using the β1-adrenergic receptor (β1AR) as a prototypical class A G-protein coupled receptor (GPCR). I have used a minimally thermostabilised turkey β1AR and expressed it functionally in insect cells using a baculovirus system. The work described here established the labelling, …
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Investigating the role of ICL3 in β1-adrenergic receptor activation
… The thermostable turkey β1-adrenergic receptor (tβ1AR) is a prototypical class A GPCR widely used in structural studies and is activated by catecholamine ligands, adrenaline, and noradrenaline. Although many crystal structures of tβ1AR are published, there is little known about the intracellular …
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Mechanisms of multipass membrane protein biogenesis
… reconstitution of β1-adrenergic receptor (β1AR) insertion in-vitro, which placed EMC at an early step during co-translational insertion of the first TMD (TMD1). In the absence of EMC, TMD1 was topologically inverted or failed to insert altogether. EMC and SRP receptor were sufficient for …