Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"β1-adrenergic receptor"”.
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Investigating the molecular signatures of β1-adrenergic receptor activation
… I have investigated the molecular signatures of receptor activation, using the β1-adrenergic receptor (β1AR) as a prototypical class A G-protein coupled receptor (GPCR). I have used a minimally thermostabilised turkey β1AR and expressed it functionally in insect cells using a baculovirus system. …
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Investigating the role of ICL3 in β1-adrenergic receptor activation
G protein-coupled receptors (GPCRs) are 7-transmembrane (7-TM) alpha helical membrane proteins involved in a myriad of physiological functions and have implications in many diseases. GPCRs are important targets for ~35% of commercial drugs. Activation of GPCRs by external signals and through …
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Characterisation of the conformational landscape of the β1-adrenergic receptor and development of a strategy towards NMR studies of the protease-activated receptor 1
… of the minimally thermostabilised avian β1-adrenergic receptor (tβ1AR) using solution state nuclear magnetic resonance (NMR) spectroscopy. The tβ1AR is a class A G-protein-coupled receptor (GPCR) and the human counterpart is an important drug target in diseases of the heart. In chapter 2, …
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MOLECULAR MECHANISMS OF THE FORMATION OF ENDOCYTIC PATCHES AND THE INITIATION OF ACTIN POLYMERIZATION IN FAST ENDOPHILIN MEDIATED ENDOCYTOSIS
… cargo including macronutrients and transmembrane receptors. Fast endophilin mediated endocytosis (FEME) is a clathrin independent endocytic pathway that is responsible for the uptake of numerous receptors, many of which are major drug targets, including the exclusive uptake of the β1-adrenergic …
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Mechanisms of multipass membrane protein biogenesis
… is supported by biochemical reconstitution of β1-adrenergic receptor (β1AR) insertion in-vitro, which placed EMC at an early step during co-translational insertion of the first TMD (TMD1). In the absence of EMC, TMD1 was topologically inverted or failed to insert altogether. EMC and SRP …
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Essential Function of Ghrelin in Chronic Starvation
… cells express high levels of mRNA encoding the β1-adrenergic receptor. Ghrelin secretion from these cells was stimulated by the addition of norepinephrine or epinephrine, an effect blocked by atenolol, a selective β1-adrenergic antagonist. Treating WT mice with atenolol or reserpine, a drug that …