Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 80 for “"β-sheet"”.
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Structure and formation of β-sheet fibers
… intermediates are comprised of two helical P-sheet layers that sandwich hydrophobic side chains in between them. Small variations in amino acid side chains were also found to have substantial effects on fiber structure and self-assembly. The kinetics of matrix self-assembly were elucidated by …
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β-sheet interactions with DNA revealed by the arc repressor-operator complex
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Design and synthesis of constrained dipeptide units for use as β-sheet promoters
The study of factors promoting beta-sheet formation has recently gained interest due to the suspected involvement of beta-sheets in brain degenerative diseases such as Alzheimer's disease (AD), Creutzfeldt-Jacob disease (CJD) and bovine spongiform encephalopathy. Understanding beta-sheet formation …
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De Novo Design and Stabilization of β-Sheet Peptides for Biomimicry of ORR Enzymes
… two focuses on efforts to stabilize the β-sheet structural motif that supports the ligand environment surrounding the laccase trinuclear copper cluster (Cu₃ site). Specifically, this chapter explores how tryptophan zippers (TrpZip) mediate β-sheet formation through hairpin folds and other …
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Molecular level characterisation of apolipoprotein A-I aggregation leading to fibrils comprising of both α-helical and β-sheet structures
… produce XRD diffraction patterns suggestive of β-sheets. The inclusion of heparin, and chemical oxidation of apoA-I methionine residues, in order to mimic physiological conditions, results in an increased ThT response and aggregated material more characteristic of amyloid. Solid-state NMR …
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Coherent two-dimensional infrared spectroscopy : a study of coupled vibrations
… and globular proteins with antiparallel (AP) β-sheet domains is studied to identify 2D markers of AP β-sheet conformation. The experiments on β-hairpins and proteins with varying percentage of β-sheet character showed that the formation of cross peaks between the two characteristic vibrational …
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Structure of the GP16 ATPase from the φ29 dsDNA packaging motor
… which six conserved β-strands form a central β-sheet, and adjacent β-strands are linked by intervening α-helices, and that the protein is a member of the ancient P-loop additional strand catalytic E (ASCE) NTPase superfamily. The active site responsible for ATP hydrolysis is located on one side …
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Plant proteins as multifunctional additives in polymer composites
… for high rigidity and stability due to high β-sheet content. In Chapter II, trypsin hydrolyzed wheat gluten (THWG) proteins were incubated in aqueous PVA solutions, then the composite solutions were air dried and compression molded into films. Anisotropic protein aggregates formed through a …
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SPECIFIC RESIDUES WITHIN PSEUDOMONAS AERUGINOSA AmrZ ARE REQUIRED FOR TRANSCRIPTIONAL REGULATION OF VIRULENCE FACTORS CONTRIBUTING TO INFECTION
… and Mnt. AmrZ contains a predicted DNA-binding β-sheet and two α-helices that contribute to oligomerization, forming the characteristic RHH motif. AmrZ contains an additional carboxy terminal domain believed to be involved in higher order oligomerization and a short amino terminal domain of …
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Synthesis and Characterization of New Cyclic and Acylic Ferrocene Peptide Conjugates
… of synthesis that was done was the attempt at β-sheet formation using Fc as a scaffold to align peptide strands. Two systems were studied in this thesis [Fc(n’-AA-OMe)(1-AA)]₂-1,4butyl diamine. (AA =Ala (8), Gly (9)). Both were studied by ¹H NMR to evaluate the presence of hydrogen bonding …
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Computational Development for Secondary Structure Detection From Three-Dimensional Images of Cryo-Electron Microscopy
… elements (SSEs) such as alpha-helices and beta-sheets can still be detected. The accuracy of SSE detection from the volumetric protein density images is critical for <em>ab initio</em> backbone structure derivation in cryo-EM. So far it is challenging to detect the SSEs automatically and …
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Biomimetic Surface Coatings from Modular Amphiphilic Proteins
… of a surface-active, amphiphilic block β-sheet domain linked to a disordered, water-soluble block with a terminal functional domain. Several types of functional domains were investigated, including sequences that act as ligands for cell surface receptors and sequences that act as templates …
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Foaming Novatein thermoplastic protein
… protein secondary structure (α-helices and β-sheets). Although Novatein softens at high temperature, it does not form a typical melt. Processing depends upon the interactions between protein, additives, and plasticisers. Highly plasticised Novatein phase separates into protein rich, …
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Structural and mutagenesis studies of soluble methane monooxygenase reductase from Methylococcus capsulatus (Bath)
… binding domain with a five-stranded parallel β-sheet surrounded by four α-helices. The FAD cofactor is bound at the interface between the two domains in a novel conformation. Near this FAD cofactor, a conserved C-terminal phenylalanine residue is proposed to act as a conformational gate for …
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Structural Changes and Chain Mobility During Processing of Bloodmeal-Based Thermoplastics
… secondary structures such as α-helices and β-sheets constraining motion in the amorphous phase, contributing to a broad glass transition region. These structures do not melt at typical temperatures encountered during extrusion processing, but are dispersed more evenly throughout an amorphous …
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Investigation of the Role of Amide I to Amide II Ratio and Alpha Helix to Beta Sheet Ratio of Faba Bean Seeds in the Determination of Microbial Protein Synthesis and Animal Performance and Metabolism in Ruminant Livestock Systems.
… of amide I to amide II ratio, and α-helix to β-sheet ratio (α_β) on the protein quality (solubility and digestibility), metabolism, and bioavailability in dairy cows has not been established. Thus, the objective of this research was to evaluate the role of the protein-related spectral ratios on …
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Structure, conformational dynamics and formation of large amyloids: the case of alpha-synuclein fibrils
… by capturing the transition from α-helical to β-sheet at the atomic level using solid-state NMR; Additionally, to investigate the AS fold, the mass-per-length (MPL) measurement of the fibrils has been obtained using STEM that together with solid-state NMR restraints have been used to propose …
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Molecular characterization of a sphingomyelin binding site in the vacuolating cytotoxin of H. pylori
… in solvent exposed peptide loops between β-sheet domains. Structural comparison of these proteins with VacA led to the identification of a similar tryptophan containing aromatic cluster in the mid-region of the p55 subunit of VacA. Additionally, sequence alignment of this putative binding …
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Understand The Structure-Water-Responsive Relationship by Engineering Silk Materials
… as a result of increased silk II structures (β-sheet rich domains) or adding stiff silica nanoparticles, <em>B. mori</em> silk’s WR actuation energy density was dramatically increased from 0.2 to 1.6 MJ m<sup>-3</sup>, surpassing the energy densities of all known natural muscles. Second, we …
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Protein and RNA folding: from bulk towards high throughput single molecule experiments
… very long MD simulations of a variant of the β-sheet WW domain protein Fip35, were experimentally verified to be true. This provided an atomistic detail understanding of the folding landscape and will act as a key benchmark in unraveling the protein folding problem. Thirdly, protein and RNA …
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