Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"β-lactamases"”.
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Sélection et caractérisation de Nanobodies inhibiteurs de métallo-β-lactamases
… des facteurs de résistance. La production de β-lactamases par des souches infectieuses est le principal mode de résistance aux antibiotiques à noyau β-lactame. Ces enzymes hydrolysent le noyau β-lactame de ces antibiotiques, les empêchant ainsi d’exercer leur action lytique. Parmi les …
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Characterization of β-lactamases and Porins in Uropathogenic E. coli
… resistance mechanisms, namely plasmid-encoded β-lactamases. These enzymes include extended spectrum β-lactamases, AmpC cephalosporinases, and serine-carbapanemases. Decreased drug influx due to outer membrane porin defects can confer resistance to the carbapenems when paired with the production …
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Discovery and optimization of inhibitors and probes that target New Delhi metallo-[beta]-lactamase
… of β-lactam hydrolyzing enzymes, known as β-lactamases, threatens their clinical efficacy. β-lactamases typically have a conserved serine in their active site that serves as a nucleophile in hydrolysis of the β-lactam substrate. Codrugs in the form of covalent inhibitors that target this …
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Evaluation of the Interplay between β-Lactamase Expression and Porin Loss in β-Lactam Susceptibility Profiles in Escherichia coli
… driven by the acquisition of Extended-Spectrum β-Lactamases (ESBLs) and carbapenemases. However, β-lactam resistance in E. coli is often multifactorial, arising from different mechanisms such as the combined effects of β-lactamase production, alterations in outer membrane permeability, and …
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Investigations of Carbapenem-resistant Klebsiella species and associated clinical considerations
… to β-lactams is mediated via extended-spectrum β-lactamases, AmpC type β-lactamases and carbapenemases combined with porin loss. Carbapenems are the antibiotics of last resort. The emergence of carbapenemase-producing organisms (CPOs) has led to Public Health England introducing a national toolkit …
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Beyond MICS: Determining the Role of Porin Production and β-Lactamase Expression in Resistance and Cellular Physiology of Klebsiella pneumoniae
… to β-lactam antibiotics through expression of β-lactamases and downregulation of outer membrane porins. However, the extent to which these mechanisms interplay in a resistant phenotype is not well understood. β-lactamase expression has long been presumed to have a previously unidentified fitness …
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Combatting β-lactamase-mediated antimicrobial resistance: from novel assays for inhibitor discovery to new diagnostics
… validated using a panel of clinically relevant β-lactamases and was applied to quantitatively study the potency of a selection of clinically used inhibitors, as well as non-clinical compounds reported in the literature. This method prioritizes hits which exhibit activity against cellular …
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Characterization of the metallo-ß-lactamase from Pseudomonas aeruginosa, IMP-1.
… in microbes are a class of enzymes known as β-lactamases. These enzymes are effective in breaking down the most commonly prescribed antibiotics at present. This work investigates two separate metallo-β-lactamase enzymes, first IMP-1, which provides antibiotic resistance to Pseudomonas …
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Pseudomonas aeruginosa OprD-Family Porins Facilitate Imipenem Translocation Resulting in AmpC β-Lactamase Induction Contributing to the Effectiveness of Imipenem/Relebactam
… determine the contribution of the chromosomal β-lactamases, AmpC, Pib-1, and OXA-50 on imipenem susceptibility. Second, determine how relebactam potentiates imipenem in the absence of OprD. Third, to determine the contribution other OccD porins: OpdP, OpdB, and OpdB in the translocation of …
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Phenotypic and genotypic characterization of salmonella isolates from chickens and humans in South Sudan.
… tetracycline 7 (87%), erythromycin 4 (50%), β-lactamases 6 (75%), erythromycin 4 (50%), streptomycin 4 (50%) and chloramphenicol 2 (25%). The gene sul1 and sul2 (8 isolates) was the most frequently detected followed by the gene tet(D) and tet(A) (7 isolates), and blaCTX-M-15 (6 isolates). The …
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Traitement des infections à entérobactéries productrices de béta-lactamase à spectre élargi: quelles alternatives aux carbapénèmes?
… : Les entérobactéries productrices de β-lactamases à spectre élargi (BLSE) sont responsables d’un nombre important d’infections liées aux soins, mais aussi communautaires. Des alternatives thérapeutiques aux carbapénèmes devraient être utilisées, notamment à cause de l’émergence des …
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Antibiotic resistance in the gut microbiota
… Bifidobacterium species. In the case of the β- lactamases, these appear to be mis-annotated. However, through homologous recombination-mediated insertional inactivation, we have demonstrated that the putative aminoglycoside resistance proteins do contribute to resistance. In additional studies, …
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Assessing bacteriological quality of fresh black soldier fly larvae.
… genes that encode class A extended spectrum β-lactamases (ESBLs) and can be responsible for therapeutic problems due to the resistant conferred. While all Staphylococcus isolates showed resistance to cloxacillin, none of them was positive for the mecA gene. The study revealed that fresh BSFL …
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Assessing bacteriological quality of fresh black soldier fly larvae.
… genes that encode class A extended spectrum β-lactamases (ESBLs) and can be responsible for therapeutic problems due to the resistant conferred. While all Staphylococcus isolates showed resistance to cloxacillin, none of them was positive for the mecA gene. The study revealed that fresh BSFL …
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Role of extended spectrum beta lactamases producing E. coli and Acanthamoeba in urinary tract infections
… resistance caused by Extended-Spectrum β-lactamases (ESBLs) producing organisms, particularly E. coli, have become an increasing problem, and recurrent infections are not uncommon. It has been confirmed that pathogenic bacteria survive and multiply inside the protozoan parasite, …
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The role of international ‘high-risk clones’ in the emergence of metallo-b-lactamase-producing pseudomonas aeruginosa in the UK
… hospital-acquired infections. However metallo-β-lactamases (MBLs) encoding resistance to carbapenems and other β-lactam antibiotics – which are important agents for the treatment of P. aeruginosa infections – are increasingly reported in the species worldwide. This study aimed to characterise a …
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Mechanisms Involved in the Expression of the AmpC Beta-lactamase Gene blaCMY-2 in Escherichia coli
… that express plasmid-encoded AmpC β-lactamases can be resistant to third generation cephalosporins and β-lactam/β-lactamase inhibitor combinations. Infections by these bacteria are associated with increased patient morbidity and mortality. Little is known about how plasmid-encoded …
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Estudo do padrão das práticas de uso de antimicrobianos em terapia intensiva
… das penicilinas associadas aos inibidores de β-lactamases. Exposição a um regime antimicrobiano prévio não teve influência sobre o perfil de resistência dos microrganismos isolados nas primeiras amostras. O acerto na cobertura do primeiro esquema antimicrobiano prescrito analisado segundo o …
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