Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 134 for “"β-catenin"”.
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Prostate cancer stem cell fate: β-catenin and the Wnt pathway
… of tumour cells. Wnt activity and β-catenin signalling have been associated with different types of cancer and microarray data from our laboratory highlighted upregulation of members of the Wnt pathway in primary prostate cancer stem cells. Therefore, the aim of this study was to …
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Defining the molecular basis for the β-catenin and CDC73 interaction
… Gene specific transcription factors, including β-catenin, a component of the Wnt signaling pathway, are used to regulate gene expression in response to developmental or environmental cues. Previous studies reported that β-catenin binds to the central region of CDC73, a subunit of the Polymerase …
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Tumor Response TCF-4/β-Catenin Regulatory Elements for Enhancing Cancer Gene Therapies
… This usually results in stabilization of β-catenin protein levels, followed by transactivation of Tcf-4/β-catenin responsive genes. The effectiveness of a Tcf-4/β-catenin transcriptional enhancer element in combination with a c-fos or carcinoembryonic antigen promoter was tested for its …
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T3-induced hepatocyte proliferation requires β-catenin and is protein kinase A dependent
… stabilization and nuclear translocation of β-catenin in pericentral hepatocytes with concomitant increase in cyclin-D1 expression. T3 administration to wild-type (WT) mice resulted in increased hepatocyte proliferation, however no mitogenic response in hepatocytes to T3 was evident in the …
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Estrogen Regulation of the Wnt/β-catenin Pathway in Osteocytes in Response to Mechanical Loading
… involved in sensing mechanical loads. The Wnt/β-catenin pathway is activated in the osteocyte upon mechanical loading. The role of estrogen (specifically estrogen loss) in regulation of this pathway in osteocytes is not fully understood. I hypothesize that estrogen is a critical factor in the …
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Investigating the effects of Wnt/β-catenin Signalling on Melanoma Cell Metabolism and Mitochondrial Dynamics
… of an intracellular signalling molecule called β-catenin. In melanoma cells, Wnt/β-catenin signalling has been implicated as a key regulator of cellular invasion and metastasis. Using both transient and stable enhancement of Wnt/β-catenin signalling, I have found that mutation–based dysregulation …
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Morphological classification of childhood medulloblastomas with β-catenin immunohistochemistry and mycn fluorescent in situ hybridization
… study was to describe the expression status of β-catenin, and MYCN, using IHC and FISH respectively, and to correlate these findings with clinico-pathological and demographic characteristics and clinical outcome. Materials and Methods This study was a nested retrospective analytical study, …
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Genome-wide CRISPR Screens to Uncover Novel Therapeutic Targets in Wnt-β-catenin Driven Gastrointestinal Cancers
… in constitutive activation of the Wnt-β-catenin signalling pathway. Wnt-β-catenin signalling is a positive regulator of stem cell self-renewal in normal tissues, but cancer cells may take advantage of it to promote their proliferation and survival. Despite frequent cancer cell reliance on …
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The Localization of β-catenin During Xenopus Kidney Development: A Look into β-catenin's Role in Kidney Development
… signaling regulates transcription through β-catenin. β-catenin coordinates cell-cell adhesion: β-catenin interacts with cadherins to link cell junctions to the cytoskeleton. However, the dynamic localization of β-catenin is still poorly understood. This research will help gain a deeper …
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Systemic Leptin Modulates the Expression of E-cadherin, β-catenin in the Ovary of Dietary-Induced Obese Infertile Rats
… Recent evidence indicates Ecadherin/ β-catenin complex, which is a structural constituent of adherens junction, is expressed in the rat ovary during folliculogenesis. We hypothesized that systemic leptin modulates the expression of E-cadherin and β-catenin in dietary-induced obese …
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Selen, Selenoproteine und der Wnt-Signalweg : Regulation der gastrointestinalen Glutathionperoxidase durch β-Catenin und Beeinflussung des Wnt-Signalwegs durch den Selenstatus
… mRNA von Schlüsselgenen des Wnt-Signalwegs wie β-Catenin, Gsk3β, Dvl2, Tle2, Lef1 und c-Myc auf Schwankungen des Selengehalts reagiert. Vor allem die Induktion von c-Myc, einem Zielgen des Wnt-Signalwegs, deutet darauf hin, dass dieser im Selenmangel tatsächlich aktiver ist als bei selenadäquater …
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A morphologic and immunohistochemical analysis of gastric adenocarcinoma with regard to the presence of E-cadherin and localisation of β-catenin staining
Includes abstract. Includes bibliographical references.
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Beta-catenin Complexes in Colorectal Cancer
… that is disrupted in colorectal cancer and β-catenin is the key mediator of Wnt signalling. β-catenin is a multifunctional protein with roles in Wnt signalling and cell adhesion. I aimed to understand the relationship between the main interactions and functions of β-catenin. Specifically, I …
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The role of beta-catenin in the development of fetal ovary and female germ cells
… the ones that signal via the canonical β-catenin pathway, are expressed in fetal gonads, suggesting their intimate association with β-catenin and potential role in regulating ovary development. Thus, the central hypothesis of my studies is that the canonical β-catenin signaling pathway is …
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New Insights On The Role of Jmjd2A In Cancer Progression
… in mediating activation of the canonical Wnt/β-catenin pathway, a highly conserved and complex signaling cascade that ultimately leads to nuclear accumulation of β-catenin. Nuclear β-catenin serves as a transcriptional coactivator by forming a transcriptional complex with TCF to activate Wnt …
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Role of ß-catenin and Leukotriene in Colon Cancer Progression
… common cancer worldwide. Deregulation of Wnt/β-catenin signalling pathway is an early hallmark of colon cancer. Were nuclear accumulation of β-catenin is a marker of activated canonical Wnt/β-catenin signaling. One of the risk factors for development of colon cancer is inflammatory bowel …
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Towards development of new strategies for inhibiting skin cancer progression
… MMTV Integration Site Family (Wnt)/β-catenin signalling is upregulated in many cancers and is important for keratinocyte proliferation. Gene expression analysis has indicated that Wnt/β-catenin signalling is altered in cSCC. In the second part of this work, I investigated the …
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INVESTIGATING ALTERNATIVE SPLICING REPROGRAMMING REGULATED BY THE E-CADHERIN/B-CATENIN AXIS
… this dysregulation, pinpointing E-cadherin and β-catenin as central players in myosin VI AS regulation. β-catenin's nuclear translocation induces myosin VIshort expression, while its depletion rescues myosin VIlong. Furthermore, we uncovered β-catenin's broader involvement in AS oncogenic …
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