Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"β-amyloid"”.
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The effects of anticholinesterases and β-amyloid pathology on neurotrophin signaling in the mouse brain
Alzheimer s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia. One promising approach to tackle AD is the protection of neurons and restoration of synaptic connections with neurotrophic factors, such as nerve growth factor (NGF) and brain-derived …
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The Clinical Determinants of Plasma β-amyloid and Its Association with Structural and Functional Vascular Changes
<b>Background</b>: β-amyloid plaque deposition is a pathological hallmark of Alzheimer’s disease and cerebral amyloid angiopathy. However, β-amyloid has also been shown to possess direct vasoactive properties and increased plasma β-amyloid has been associated with endothelial dysfunction in …
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Pathomechanismen der sporadischen Einschlusskörperchenmyositis
… Akkumulationen von abberanten Proteinen wie β-Amyloid und hyperphosphoryliertem Tau, aber auch ausgeprägte entzündliche Reaktionen der Muskelfasern, wodurch diese selbst dazu beitragen von zytotoxischen T-Zellen attackiert zu werden. Allerdings ist bisher unzureichend verstanden, ob es einen …
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Synthesis And Characterization Of New Gd3+-Containing Complexes As Potential Targeted Contrast Agents For Magnetic Resonance Imaging
… research described in this thesis, myelin and Β-amyloid aggregates were selected as targets because they are important in diagnosing neurological diseases. The myelin-targeted complexes were designed to mimic the structural features of a known myelin-specific histology stain, and ex vivo …
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Pathologische Veränderungen im Thalamus in einem Tiermodell für die Alzheimer-Krankheit
Die Akkumulation von β-Amyloid-Plaques und neurofibrillären Tangles, die aus hyperphosphoryliertem Tau-Protein bestehen, sind typische pathologische Veränderungen, welche bei der Alzheimer-Erkrankung (AD) vorkommen. Die dafür verantwortlichen mutierten humanen Gene werden zur Erforschung in …
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Prediction value of genetic and neuromarkers in blood and liquor in patients with severe traumatic brain injury
… (NFL, CSF, study IV), Tau (CSF, study II), β-amyloid (1-42) and amyloid precursor-proteins (CSF & plasma, study I) were enhanced after a sTBI. Further, we investigated if these levels were correlated to outcome, neurology and patient ability of daily living 1-year post-trauma. Finally, we …
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The Neuroprotective Effects of Exercise Against Menopause Induced Alterations in Alzheimer’s Disease Neuropathogenesis
… failure on the neuroinflammatory response and β-amyloid plaque deposition through the evaluation of overall microglial expression, homeostatic microglial expression, and β-amyloid plaque deposition in subregions of the hippocampus. We performed a triple immuno-fluorescence stain (Iba1, Tmem119 …
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The Role of Apolipoprotein E in Pregnancy-Associated Protein Misfolding and Risk of Preeclampsia
… conformations of misfolded proteins (including β-amyloid) in urine, serum, and placenta. Protein misfolding and aggregation have been studied extensively in prototype protein conformational disorders such as Alzheimer’s (AD) and targeting of these pathogenic processes has recently led to new …
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Regulation of the Gene Encoding Thrombin-Activable Fibrinolysis Inhibitor in Non-Hepatic Cells
… possess a secretase-like activity that cleaves β-amyloid precursor protein to form β-amyloid, a process involved in the onset of Alzheimer's disease. In this thesis, we report the identification of CPB2 mRNA and TAFI protein in various vascular and inflammatory cells. Specifically, we describe the …
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Exploring Risk Factors of Alzheimer’s Disease Using Mouse Models
… discordant mRNA/protein expression of amyloidome components, suggesting an interaction with β-amyloid (Aβ) may decrease protein degradation and trafficking.</p>
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Modulation of Histone Deacetylases Attenuates the Pathogenesis of Alzheimer's disease
… die HDAC-Inhibition keine Auswirkungen auf die β-Amyloid-Pathologie. So könnte bei Alzheimer-Patienten eine kognitive Verbesserung unabhängig von der laufenden Pathologie sein und die HDAC-Inhibition könnte die kognitive Regeneration bei AD signifikant begünstigen.Neben der Histon-Acetylierung, …
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Multi-modality imaging assessment of cerebral small vessel disease biomarkers after stroke due to spontaneous intracerebral haemorrhage
… cerebral small vessel diseases (SVDs). Cerebral amyloid angiopathy (CAA) and arteriolosclerosis (non-CAA SVD) are the two main types of SVD associated with ICH. The risk of recurrent ICH and post-stroke dementia may be higher with CAA-associated ICH compared with non-CAA SVD-associated ICH. It …
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Microglial Phagocytosis of Bacteria and Synapses
… calreticulin, galectin-3, apolipoprotein E and β-amyloid in microglial phagocytosis of bacteria were studied. Microglia activated with bacterial endotoxin upregulated and released extracellular calreticulin and galectin-3 in culture, and both proteins could bind the surface of the gram-negative …
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Ketoacids as antioxidants in human astrocytes exposed to oxidative and aluminum stress.
… E, an essential biomolecule in lipid and β-amyloid metabolism, was found to be down-regulated under aluminum stress, an observation that was reversed by OAA recovery. Hence it appears that the ketoacids play a critical role in quelling ROS in human astrocytes.
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Die Expression von High Mobility Group Box 1 (HMGB1) und dessen Receptor for Advanced Glycation Endproducts (RAGE) als Pathomechanismus der sporadischen Einschlusskörpermyositis
… mit und ohne den HMGB1-Inhibitor Box A auf die Amyloid-Aggregatbildung und den Zelltod erforscht.Die quantitative Auswertung der seriellen immunhistochemischen Färbungen zeigte, dass das β-Amyloid Vorläuferprotein APP und das Zellstress-Molekül αB-Crystallin früh in normal erscheinenden Fasern …
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Terahertz Raman Spectroscopy of Organic Molecules in Plasmonic Nanogaps
… of Alzheimer’s Disease (AD), the archetype of amyloid diseases. The polymerization of the peptide β-amyloid is considered to be central to the pathogenesis of AD. Because of the delocalized nature of THz-frequency molecular vibrations, THz SERS has the potential to directly distinguish …
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Development of peptide inhibitor nanoparticles (PINPs) for treatment of Alzheimer’s Disease
… the best carrier technology for our β-amyloid (Aβ) aggregation inhibitors by developing three types of liposomes (a) plain liposomes, (b) MAL-PEG liposomes, and finally the combination of retro-inverted peptide RI-OR2- TAT (Ac-rGffvlkGrrrrqrrkkrGyc-NH2) attached onto the surface of …
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Untersuchung genetischer und geschlechtlicher Einflüsse in der Alzheimerpathologie anhand des Maustiermodells 5XFAD
… die Erkrankung durch intra- und extrazelluläre β-Amyloid-Ablagerungen, intrazelluläre Neurofibrillen, Synapsen- und Neuronenverluste charakterisiert. Der typischerweise auftretende Gedächtnisverlust wird durch den Neuronenverlust, die Synapsendegeneration und inflammatorische Prozesse vermittelt. …
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An investigation into the effects of inorganic element status on the accumulation and deposition of amyloid in various diseases.
… diseases are reported to be associated with amyloidogenic peptides and proteins, for example, β amyloid (Αβ) in senile plaques of Alzheimer's disease and β2 microglobulin (β2M) deposition in dialysis related amyloidosis. The major factor for amyloidosis appears to be an increase in the …
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Effects Of Altering The Peroxisomal Redox State In Models Of Degenerative Disease
… in a rat cell model of Alzheimer's disease, β-amyloid peptide-induced neuronal toxicity is significantly reduced.</p>
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