Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"β-adrenergic receptors"”.
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Dhhc5 Regulates Beta-Adrenergic Signaling In The Heart Through Palmitoylation of G Alpha Proteins
… work in this dissertation investigated whether β-adrenergic stimulation led to stimulus-dependent palmitoylation of downstream signaling proteins in immortalized and primary cell models. I found that β-adrenergic stimulation led to rapidly increased Gαs and Gαi palmitoylation only in primary …
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AKAP12 Signalosome Regulates Cardiac β2-Adrenergic Receptor Signaling
… downregulation, and recycling of β Adrenergic Receptors (βAR). Several AKAPs have been associated with cardiac function. AKAPs cardiac expression levels and intracellular distribution are altered under pathological conditions; however, AKAP12 cardiac roles are unclear. In this study, …
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T-type Calcium Channels in Arterial Smooth Muscle: Activity, Regulation and Function
… target of vasodilatory kinases. In particular, β-adrenergic receptors and downstream activation of protein kinase A selectively inhibited CaV3.2 currents. Nitric oxide additionally suppressed CaV3 channels through protein kinase G signaling. Subsequent work on rat and mouse arteries revealed an …
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Neuronal regulation of haematopoietic stem cell ageing and age-related blood disorders through the microenvironment
… in and out of the BM through the activation of β-adrenergic receptors (β-ARs). However, whether BM sympathetic-adrenergic signalling regulates other functions of HSCs remains poorly understood. Upon ageing, HSCs are functionally impaired, characterised by increased proliferation, decreased …
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Novel Mechanisms of Β-Adrenergic Signaling In Prostate Cancer Progression
… it has been found that activation of β-adrenergic signaling pathway leads to aggressive variants of prostate cancer. β-adrenergic signaling involves the activation of β-adrenergic receptors (ADRBs), eventually leading to increased activation of cAMP response element-binding protein …
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A NEUROPHARMACOLOGICAL ANALYSIS OF LEARNED HELPLESSNESS IN RAT (GENETICS).
… rats with regard to the 5-HT₂ and β-adrenergic receptors in the frontal cortex. Based on previous studies and the results from Experiment I, one could argue that there exists a genetic component in LH. The results from Experiment II suggest a strong genetic component to LH, not unlike …
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Investigating the effects of enhanced catecholamine stimulation in stem cell-derived cardiomyocytes
… mediated through the sustained stimulation of β-adrenergic receptors by catecholamines via mechanisms that are not yet clear but proposed to involve altered signalling of molecules such as stress-response growth factors. One such growth factor is the transforming growth factor beta 1 (TGF-β1) …
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Protein kinases in hormonal regulation of adipocyte metabolism.
… Catecholamines are hormones that bind to β-adrenergic receptors and act by increasing cellular levels of cAMP, which in turn activates protein kinase A (PKA). We find that in response to such β-adrenergic stimuli, SIK3 is phosphorylated on multiple serine and threonine residues. This 10 …
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Adrenergic Receptor Gene Expression in Bovine Leukocytes and Effects of Adrenergic Agonists on Neutrophil and Eosinophil Function
… (E) and norepinephrine (NE). The α- and β-adrenergic receptors (ARs) are encoded by 6 α- and 3 β-AR genes and these ARs mediate interactions between the stress hormones E and NE and immune cells. However, AR gene expression and function have been studied to a limited extent in bovine immune …