Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"β-TRCP"”.
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Regulation of BubR1 by Ultraviolet Radiation: Implications in Skin Cancer
… Preliminary work from our lab have identified β-TRCP, an F-box containing protein, as an interacting factor for BubR1. β-TRCP is the substrate recognition subunit for the SCF (Skp, Cullin, F-box) complex, belonging to the Cullin RING E3 ubiquitin ligase (CRL) family of E3 ubiquitin ligases that …
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Investigation of p75 neurotrophin receptor and the role of its post-translational modifications in tumour cell motility and invasiveness
… beta-transducin repeats-containing protein (β-TrCP) as a novel E3- ligase that ubiquitinates p75NTR, which is independent of serine phosphorylation of the p75NTR destruction motif. In contrast to its influence on other substrates, co-expression of β-TrCP did not reduce p75NTR stability. We …
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Transcriptional and Post-Translational Mechanisms Contribute to Maintenance of Rest In Neural Tumors
… by modulation of E3 ligase or REST, SCF<sup>β-TRCP</sup>, and contribute to resistance of some cells to retinoic acid treatment.</p>
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Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules
… kinase TAOK1 and the E3 ubiquitin ligase, β−TrCP. Most of the miRNAs inducing proliferation (including miR-199a-3p) also modulated the dynamics of the actin cytoskeleton in the treated cardiomyocytes, which displayed a rounded shape and gross bundles of actin fibers at the cytoplasm …
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Dual regulation of transcription factor Nrf2 by Keap1 and the beta-TrCP/GSK-3 in cancer
… β-transducin repeat-containing protein (β-TrCP) to ubiquitinate Nrf2 by Skp1-Cul1-F-box (SCF) ubiquitin ligase through the Neh6 domain of Nrf2. Several research groups have shown that induction of ARE-driven genes can be regulated by phosphoinositide 3- kinase- protein kinase B …
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Oxygen-dependent regulation of the activating transcription factor-4 (ATF-4)
… beta-Transductin repeat containing protein (ß TRCP) nachgewiesen. Allerdings konnte mit Hilfe von Pull-down Experimenten oder durch Runterregulation der ß-TRCP mRNA Expression gezeigt werden, dass die normoxische Degradation von ATF-4 nicht ß-TRCP-abhängig ist. Auch eine Beteiligung der …