Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"β-Hematin"”.
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Nonclassical Mechanisms to Inhibit β-Hematin Crystallization Illuminate the Cooperative Action of Antimalarials
… development. This dissertation uses β-hematin, the synthetic analogue of hemozoin, as a mechanistic model to examine crystal structure, growth, nucleation, precursor populations, and drug action under biomimetic conditions. Structural analyses show that β-hematin and hemozoin obtained …
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Synthesis, physicochemical and biological evaluation of N-dealkylated metabolites of antimalarial pyrido[1,2-a]benzimidazoles and related compounds containing a Mannich base side-chain
… parasite (Plasmodium falciparum) growth and β-hematin formation inhibition activities, turbidimetric solubility, cytotoxicity, and microsomal metabolic stability in mouse liver microsomes were evaluated. To investigate structure activity relationships (SARs), the study was broadly diversified …
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Antimalarial Evaluation of Quinoline-triazoleMn(I) and Re(I) PhotoCORMs
… indicate that they potentially work via β-hematin inhibition, with the metal complexes being greater inhibitors than CQ. Upon photo-induced CO-release, the β-hematin inhibition of complex Mn-1 increases drastically.
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Investigating the structure-function relationships of Plasmodium Haem Detoxification Protein and Phosphatidylinositol 4-kinase
… methods. Refolded HDP was evaluated for β-hematin formation activity, but the results indicated β-hematin formation was mediated by sodium dodecyl sulfate used in the assay rather than by HDP. HDP was co-crystalised in the presence of haem but crystals diffracted poorly. Evaluation of the …