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Showing 1 to 20 of 61 for “"β-Cyclodextrin"”.
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Polypyrrole modified with sulfated β-cyclodextrin: characterization and application in the sensing of viologens
… (ppy) matrix doped with the anionic sulfated β-cyclodextrin (sβ-CD) was electrosynthesized and characterized. This modified polymer, ppysβ-CD, was used as a sensor for the detection of three compounds, methyl, ethyl and benzyl viologen. Methyl viologen is commonly known as paraquat and it is one …
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The effects of Hydroxypropyl-β-Cyclodextrin on the American Flagfish (Jordanella floridae) over one complete life-cycle
… of particular interest is hydroxylpropyl-β-cyclodextrin (HPβCD), the active ingredient in Febreeze®, and widely used for many applications. HPβCD is amphiphilic, toroidal in shape, and able to form non-covalent inclusion complexes with a variety of guest molecules. HPβCD has been shown to …
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Evaluating the Mechanisms of 2-Hydroxypropyl-β-Cyclodextrin and Liver X Receptor Agonists as Potential Therapies for Niemann-Pick Type C Disease
… two separate compounds (an LXR agonist and a cyclodextrin) have been shown to increase lifespan in the Npc1-/- mouse model. Although both of these potential therapies are known to alter cholesterol dynamics in the cell, the molecular mechanism(s) through which they are able to correct the …
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SYNTHESIS, CHARACTERIZATION, IN VITRO EVALUTION, AND PRECLINICAL PROFILING OF β-CYCLODEXTRIN POLYROTAXANE FAMILIES FOR USE AS POTENTIAL NIEMANN-PICK TYPE C THERAPEUTICS
Niemann-Pick Disease Type C (NPC) is a rare, autosomal recessive genetic disorder featuring a loss of proteins responsible for unesterified cholesterol (UC) trafficking through the late endosomes/lysosomes (LE/LY) of every cell of the body. Disruption of this pathway leads to abnormal accumulation …
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Preparation and solid state properties of cyclodextrin complexes of selected drug molecules
… of these drugs. This molecule is a cyclodextrin and is known to form inclusion compounds with various drug molecules. The preparation of β-cyclodextrin CP-CD), y-cyclodextrin (y-CD), heptakis(2,6-di-OJ, methyl)-β-cyclodextrin (Dimeb) and heptakis(2,3,6·tri-0-methyl)- β-cyclodextrin …
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Adsorption behaviour of molecularly imprinted-beta-cyclodextrin polymers prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization for selective recognition of benzylparaben
… of MIPs, the modification monomer based on β-cyclodextrin (β-CD) and the essential of reversible addition�fragmentation chain transfer (RAFT) polymerization process were studied to generate potential MIPs. The study focuses on the characterization and adsorption behaviour of MIPs for selective …
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Drug-cyclodextrin complexes: an approach to enhance the solubility and dissolution properties of poorly soluble drugs
… complexation between different drugs and cyclodextrins (econazole and α-cyclodextrin; indomethacin and methyl-β-cyclodextrin; olanzapine and methyl-β-cyclodextrin; flurbiprofen and methyl-β-cyclodextrin) in order to enhance the apparent solubility and dissolution properties of drugs. …
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The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs
The cyclodextrins and their derivatives have been utilised as complexing agents for a wide range of pharmaceutical compounds, through their ability to include small molecular weight molecules inside an annular cavity formed by linked glucose residues of varying number. The non-steroidal …
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Synthesis and characterisation of new multi-component compounds containing the non-steroidal anti-inflammatory drugs fenbufen and S(+)-ibuprofen
… employed to synthesise salts, co-crystals and cyclodextrin inclusion complexes containing these drugs. All newly discovered phases were characterised using single-crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), hot stage microscopy (HSM), Fourier transform infrared (FT-IR) …
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Development and characterisation of biosynthetic hydrogels for wound management applications
… been counteracted by using solubility enhancing cyclodextrins. In this study, water soluble curcumin:hydroxypropyl-β-cyclodextrin supramolecular inclusion complex was produced by a solvent evaporation method. The ratios of solvents to solubilise curcumin and hydroxypropyl-β-cyclodextrin were …
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Ensuring the Stability of Natamycin on Shredded Cheese
… in natamycin degradation studIes. The use of cyclodextrins to increase water solubility was tested to see if a uniform distribution of natamycin over the shredded cheese could be done effectively. Furthermore, a known application of mold was performed to see how well natamycin and each of its …
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The Formation of an Electrochemical Sensor for the Selective Detection of Dopamine
… and performance of a polypyrrole-sulfonated β-cyclodextrin (PPy-SCD) film that can be used as novel dopamine (DA) sensor. This material exhibited a higher sensitivity to DA in comparison to the several other polypyrrole modified electrodes that were investigated in this study and it was also …
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Biopharmaceutical approaches for improved drug delivery across ocular barriers
… acid (EDTA)) and formulation approaches (cyclodextrins and solid lipid nanoparticles (SLNs)) were evaluated in terms of their ability to improve the ocular bioavailability of hydrophilic and lipophilic compounds, respectively. A novel approach, localized modulation of RPE P-gp using …
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Design and Assembly of Block Copolymer-Modified Nanoparticles into Supracolloidal, Molecular Mimics
… of the well-established interactions between β-cyclodextrin and adamantane as the host and guest molecules. Upon the slow addition of water, particles assemble due to the host–guest interactions between the complementary block copolymers, as the hydrophobic adamantane moieties are driven within …
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Investigations of the solution properties of both unmodified and modified cyclodextrins
… on investigating the anomalous solubility of β-cyclodextrin using time correlation functions as the main tool for analysis. The primary focus is on the conformational metrics which govern the internal motions of the three main, unmodified cyclodextrins (namely a, β and y). The conformational …
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Enhancement in Degradation of Environmental Pollutants: Fenton Degradation of 2,4,6-Trinitrotoluene and Photodegradation of Deepwater Horizon Crude Oil
… neutral pH with several modifiers present: β-cyclodextrin, carboxymethyl-β-cyclodextrin, alcohols, and polyethylene glycol (PEG, MW 200, 400, or 600 g/mol). Fenton degradation was also carried out on other nitroaromatics to better understand the reaction mechanism with PEG 400. Further …
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MULTIFUNCTIONAL SUPRAMOLECULAR DELIVERY SYSTEM FOR ENHANCING TUMOR IMMUNOTHERAPY
… tumor immunotherapy efficiency through β-cyclodextrin (β-CD)-based delivery systems. By utilizing host-guest supramolecular chemistry, β-CD carriers were combined with hydrophobic molecules lonidamine (LND) and indocyanine green (ICG). in additional, after functional modification, the …
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Physicochemical characterisation of cyclodextrin-drug complexes
The cyclodextrins and their derivatives are finding increasing application in the pharmaceutical industry as carrier molecules for many drugs, as complexation can result in improved physical characteristics such as increased aqueous solubility and dissolution rates. The aim of this work was to …
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Transdermal Iontophoretic Delivery Of Lipophilic Drugs
… studied by complexing with sulfobutyl ether-β-cyclodextrin (Captisol® CAP), a β-cyclodextrin derivative carrying ionizable groups to render propofol amenable to iontophoresis. The passive permeation flux of propofol was enhanced by four fold due to complexation with CAP. Application of …
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