Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"β cell survival"”.
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Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes
… the risk T-allele of rs7903146 with impaired β cell function including glucose- and incretin-stimulated insulin secretion and β cell survival. The aim of this thesis is to elucidate the function of TCF7L2 in the β cells and explain the mechanisms by which genetic variants in TCF7L2 confer the …
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Transglutaminase in the life and death of the pancreatic β-cell
… TG2 protein has been reported in numerous intracellular mechanisms, cell-surface associations, and extracellular matrix (ECM) interactions. In the pancreas, the expression of TG may be fundamental to the insulin-secretion function of β-cells, and associated diabetic disorders. The functional …
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Erythropoietin Signaling in Pancreatic Beta Cells in Homeostasis and in Models of Type 1 and Type 2 Diabetes
… of diabetes is the insufficient functional β-cell mass to maintain euglycemia; therefore, the promotion of β-cell survival and growth is a fundamental goal for diabetes prevention and treatment. Evidence has suggested that erythropoietin (EPO) exerts cytoprotective effects on non-erythroid …
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The anti-diabetic mechanisms by isoflavone genistein
… dysfunction and significant loss of functional β-cells. As such, the search for novel agents that promote β-cell survival and preserve functional β-cell mass are one of the essential strategies to prevent and treat the onset of diabetes. Genistein, a flavonoid in legumes and some herbal medicines, …