Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"αvβ5"”.
-
Expression and function of the αVβ5 integrin during human B lymphopoiesis
The integrin αVβ5 is a receptor for sCD23 molecule and the αVβ5-CD23 interaction sustains proliferation of the pre-B cell line SMS-SB. This thesis describes further investigation into the role of αVβ5 integrin during human B cell development. B cell development in the bone marrow involves stepwise …
-
Generierung von Antikörper-Bibliotheken und Selektion von Antikörpern gegen die Integrine αvβ5 und α5β1 mittels Phagen-Display-Technologie
… gegen die Integrine αvβ5 und α5β1 generiert und spezifische Fab-Antikörper mittels Phagen-Display-Technologie selektiert. Dafür wurden zum einen das Antikörper-Repertoire immunisierter Kaninchen und zum anderen die humane Fab-DNA-Vorlage des Plasmids pAra H6HA-TT …
-
Correlation between the expression of integrins and their role in cancer progression. Expression pattern of integrins αvβ3, αvβ5 and α5β1 in clinical and experimental tumour samples
… effect of novel antagonists of α5β1, αvβ3 and αvβ5 integrins on cancer cell migration, a key process in tumour cell dissemination. Immunohistochemistry was used to evaluate the expression of α5, αv, β3 and β5 integrin subunits in prostate cancer tissues. Furthermore the expression of these …
-
Alpha v beta 5 and related receptors in human B lymphocyte development
… monocytes. CD23 has been found to interact with αvβ5 and this interaction greatly enhances growth of the B cell precursor cell line SMS-SB. This interaction may have a role in the development of normal human B cells and in cancer as the integrin is expressed on both precursor and ALL cells but …
-
Integrin-ligand interactions and cytokine production by monocytic cells
… CD23 interacts with four integrins, αVβ3 and αVβ5 from the αV integrin family, and αMβ2 and αXβ2, from the β2 family of integrins. Using peptide array technology, we identified set of overlapping peptides derived from the soluble CD23 sequence that interact with integrins expressed on the …
-
Characteristic analysis of mobility inducers for neural stem cells
… So, we examined that CM-1 bound to the integrin αvβ5, known as candidate CM-1 receptor in NSCs and resulted in promoting activation of signal pathway for mobility. In migration assay using functional blocking antibody, we identified that integrin αvβ5 interacted with CM-1 and induced functional …
-
Synthetic Methodology and Application of Enamine [2+2] Cyclisations for Cyclobutane Synthesis. Development of Integrin Antagonists as Anticancer Therapeutics Towards a Total Synthesis of Providencin
… compound ICT9055 but also had activity against αvβ5 and therefore showed greater inhibition of migration of DLD-1 cells. This showed the ability to modify this scaffold for multi integrin antagonism and potential benefit of this. Synthetic studies towards the marine natural product providencin …
-
Links Between Adhesion Signalling and Cell Cycle Regulation in Bladder Cancer Cells
… cancer cell proliferation through integrin αVβ5 mediated mechanisms which contributed to loss of p27 and rapid progression through the cell cycle. Although deregulation of the cell cycle underlies the aberrant cell proliferation that characterises bladder cancer, a novel role of the master …
-
Functional Investigation of Dual αvβ3 and αllbβ3 Integrin Inhibition in Haematological and Solid Tumour Models
… RGD-binding integrin subfamily comprising αvβ3, αvβ5, αvβ6, αvβ8, αllbβ3, α5β1, α8β1 and αvβ1 are related to progress and spread of cancer and poor prognosis. Because of the importance of integrin biology in the regulation of cancer dissemination, the integrin receptors are being utilised as …
-
INTEGRIN ALPHAVBETA3 AS THERAPEUTIC TARGET AND IMAGING BIOMARKER FOR VASCULAR ENDOTHELIAL CELLS AND CANCER EPITHELIAL CELLS
… amounts in adult epithelia. Integrins αvβ3 and αvβ5 play important roles in promoting cancer cell biology as well. Moreover, the fibronectin-binding integrin α5β1 may promote solid tumor invasiveness. Integrin αvβ5 is normally expressed by epithelial cells but may contribute to tumor migration, …
-
Targeted Delivery of Surface Modified Nanoparticles: Modulation of Inflammation for Acute Lung Injury
… drawbacks.</p> <p>During ALI, the αvβ6/αvβ5 integrins of alveolar epithelium and endothelium, respectively play a critical role in mediating pulmonary edema in interleukin-1b (IL-1b) stimulated ALI models. A transient blockade of both integrins by antibodies (Ab) or small Arg-Gly-Asp …