Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"αSynuclein"”.
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From Gut to Brain - αSynuclein pathology spreading in a new transgenic mouse model
… and society in general. Aggregation of αSynuclein (αSyn) and presence of characteristic motor symptoms are cardinal features of PD. The onset of PD motor symptoms is however preceded by non-motor symptoms that can start decades earlier. These may be associated with initiation of αSyn …
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Non-motor symptoms in the aav-α-synuclein rat model of Parkinson’s disease: exercise as a therapeutic intervention
… both unilaterally- and bilaterally-administered αsynuclein. Furthermore, it set out to explore whether voluntary exercise could ameliorate motor and NMS in this PD model, including if exercise could protect against hippocampal-associated cognitive deficits by modulating adult hippocampal …
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Investigating the mechanisms by which PINK1 protects against Parkinson's disease
… neurodegeneration in PD and to determine whether αsynuclein and PINK1 share common mechanisms. This information will be critical for future identification of therapeutic targets. In Chapter 4, we identified significant Golgi fragmentation, mitochondrial fission and reductions in neurite length in …
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Investigating Parkinson’s Disease human iPSC-derived models through single-cell gene expression
… computational techniques that leverage toxic and αSynuclein genetic stressor conditions, and demonstrate how in-silico methods can be used to perform exploratory analysis and infer disease signatures. Using genome editing, we investigate the impact of the familial PD mutations SNCA-A35T and …