Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"α7 NICOTINIC ACETYLCHOLINE RECEPTOR"”.
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Role of Microglial α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator in Neuroinflammatory Pain Models in Mice
… is densely populated with microglial cells and α7 nicotinic acetylcholine receptors (nAChRs). Given the role of microglial α7 nAChRs in neuroinflammation, the α7 nAChRs have emerged as potential target for neuroinflammatory pain treatment. We hypothesized that microglial α7 nAChRs positive …
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Cholinergic signals promote the quiescence of normal or leukaemic stem cells through the activation of the α7-nicotinic receptor in bone marrow mesenchymal stromal cells
… decrease. Cholinergic signals activate the α7 nicotinic receptor in BM mesenchymal stromal cells (BMSCs), leading to increased CXCL12 expression and HSC quiescence. In vivo, exposure to nicotine increases endosteal HSC quiescence and impairs haematopoietic regeneration after HSC …
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Mild traumatic brain injury augments innate immune responses through neurokinin and cholinergic signaling
… mice did not. Using an FDA-approved neurokinin-1 receptor (NK1R) antagonist, aprepitant, we confirmed our previous findings that substance P (SP) is a key mediator of enhanced resistance to pneumonia. Blocking NK1R showed that mTBI-induced release of SP augments pulmonary neutrophil recruitment …
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Atomistic insights into the structure, dynamics, and regulation of integral membrane proteins
… its effective interaction with the surface receptors on the host cell, highlighting functional roles of glycans beyond surface shielding. My second project focuses on the transport mechanism of the human anion exchanger 1 (AE1), a membrane transporter that mediates rapid exchange of …