Global ETD Search
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Showing 1 to 7 of 7 for “"α7β1 integrin"”.
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The α7β1 integrin accelerates exercise-induced myogenesis
Muscle-specific transgenic overexpression of the α7β1 integrin can protect against exercise induced-injury and promote the appearance of multipotent mesenchymal-like (Sca-1+CD45-) stem cells in skeletal muscle. PURPOSE: The purpose of this study was to determine if overexpression of the α7β1 …
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α7β1 integrin regulation of skeletal muscle growth in response to mechanical loading
The α7β1 integrin has been proposed to serve as a mechanosensor and essential regulator of myofiber remodeling given its localization at the membrane and primary role in adhering the outer extracellular matrix to the inner actin cytoskeleton. However, additional work is necessary to affirm a …
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α7β1 integrin regulation of skeletal muscle growth in response to mechanical stimulation
The α7β1 integrin has been proposed to serve as a mechanosensor and essential regulator of myofiber remodeling given its localization at the membrane and primary role in adhering the outer extracellular matrix to the inner actin cytoskeleton. However, additional work is necessary to affirm a …
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Identification of a first in-class integrin enhancing small molecule for the treatment of Duchenne Muscular Dystrophy
… treatment options exist for patients. The α7β1 integrin is an additional laminin-binding heterodimeric protein at the sarcolemma that is elevated in the skeletal muscle of DMD patients and the mdx mouse model. Previous pharmacological and transgenic mouse studies have demonstrated that the …
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Integrins in muscle disease and repair
Integrin α7β1 plays an important role in maintaining adult skeletal muscle integrity and like dystrophin, provides anchorage and bidirectional signaling as a laminin receptor. The expression of α7β1 integrin was upregulated upon dystrophin deficiency arguing for the molecular compensation and thus …
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Investigation of a role for the α7 integrin as a mechanotransducer of hypertrophic signaling in skeletal muscle
The α7β1 integrin is a transmembrane protein in skeletal muscle which serves as a focal adhesion at costameres of skeletal muscle, providing a critical link between the actin cytoskeleton inside the cell with laminin in the basement membrane of the extracellular matrix. Previous research has …
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Preconditioned muscle-derived mesenchymal stem cells revitalize growth and function in aged skeletal muscle
… disabilities. Our lab has defined a role for the α7β1 integrin, a transmembrane adhesion protein, in the protection of skeletal muscle from damage associated with mechanical force during exercise. Transgenic expression of the α7B integrin isoform in mouse muscle (α7Tg) additionally enhances new …