Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"α5 helix"”.
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Receptor- G Protein Interactions in the Visual System: A Study of Structures and Mechanisms That Couple the Cytoplasmic Surface of Rhodopsin to the Nucleotide-Binding Pocket of Transducin
… with the nucleotide binding pocket via the α5 helix of Gαt. We developed an expression and assay system to characterize a large number (>50) of site-directed mutants of Gαt designed to test these hypotheses. The mutants were expressed in vitro in rabbit reticulocyte lysate and the kinetics …
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Structure and activation of the class D GPCR dimer Ste2
… studied thus far. The intracellular end of the helix H7 forms an irregular coil and sterically blocks the G protein coupling site in the inactive states. Upon agonist binding, there is a 6 Å outward movement of the extracellular end of H6, followed by a 20 Å outward movement of the …