Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"α4β2"”.
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The role of subunit interfaces in the function of (α4β2)2β2 nAChRs
… into pentamers with alternate stoichiometries (α4β2)2β2 and (α4β2)2α4. These two receptors differ in sensitivity to ACh, unitary current amplitude, selectivity for different agonists, antagonists an, and potentiation by ions or drugs. The alternate stoichiometries are present in neurones and …
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The Lipid-Facing M4 Helix of α4β2 nACh and 5-HT3A Receptors
… of mutations in the M4 helices of the 5-HT3A and α4β2 nACh receptors. I used a membrane potential-sensitive fluorescent dye, two-electrode voltage clamp and manual patch-clamp for functional characterisation of mutant receptors in HEK293 cells and Xenopus oocytes, and radioligand binding and …
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The role of subunit interfaces in the function of nicotinic acetylcholine receptor
… such as cognition, mood, reward and analgesia. α4β2 nAChRs have been implicated in a wide range of diseases such as depression, Alzheimer’s, Parkinson’s, Schizophrenia and a type of familial epilepsy. Also, α4β2 nAChRs are necessary and sufficient for the rewarding and reinforcing effects of …
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ALPHA4BETA2 NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS: FROM SUBTYPE SELECTIVE TO STOICHIOMETRIC ISOPHORM SELECTIVE PARTIAL AGONISM.
This PhD thesis focuses on the study of the α4β2 nicotinic acetylcholine receptors (nAChRs). This dissertation is divided into two parts. The first part is centred on the design, synthesis, and biological evaluation of compounds selective for the orthosteric and unorthodox binding sites of the α4β2 …
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Structural and molecular determinants of the sensitivity of alpha4beta2 nicotinic acetylcholine receptors to the allosteric ligand desformylflustrabromine
… on a positive allosteric modulator of the human α4β2 nAChR, desformylflustrabromine (dFBr), which was found to exert its potentiating effects on this receptor by binding to a site in the transmembrane region of the α4 subunit. α4β2 nAChRs are the most abundant nAChR type in the brain, where they …
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Συνέκφραση και μελέτη υπομονάδων του νικοτινικού υποδοχέα ακετυλοχολίνης ανθρώπινων νευρικών κυττάρων
… κυρίως σε νευρικού και μυϊκού τύπου. Ο νευρικός α4β2 nAChR έχει εκφραστεί και μελετηθεί με τεχνικές όπως πρόσδεση αγωνιστών-ανταγωνιστών και ηλεκτροφυσιολογικές αναλύσεις. Όμως δομικές μελέτες υψηλής ανάλυσης όπως η κρυσταλλογραφία ακτινών-Χ, πάνω σε αυτόν τον υποδοχέα δεν έχουν ακόμα αναφερθεί …
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INVESTIGATING THE ROLE OF α6 and α4 CONTAINING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS IN NICOTINE AND COCAINE CONDITIONED PLACE PREFERENCE TESTS IN MICE.
… in nicotine and cocaine reward. α6β2* and α4β2* nAChRs are highly expressed in midbrain, which is known to be critical for the incentive salience associated with natural and artificial (drug) reward. Our goal was to assess the role of α6β2* and α4β2* nAChRs in nicotine and cocaine reward …
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Regulation of Expression and Function of Neuronal Nicotinic Receptors by Accessory Subunits
… and trafficking of these channels. The α4β2 and α3β4 subtypes are the most abundantly expressed nAChRs in the central and peripheral nervous system, respectively, and are key mediators of nicotine dependence and withdrawal. These nAChRs are heteropentameric ligand-gated ion channels that …
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Unravelling the relationship between cigarette smoking and language development
… (nAChRs), among which the subtypes α7 and α4β2, have been linked to cognitive functions such as working memory (WM). Moreover, recent work linked a rare variant in Resistant to inhibitors of cholinesterase 3 (RIC3; NM_024557.4:c.262G>A, NP_078833.3:p.G88R) to a unique ability to speak …
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Understanding the Atomic-Scale Mechanisms of the Human [alpha]4[beta]2 Nicotinic Acetylcholine Receptor
… the plasma membrane. The heteropentameric α4β2 subtype is the most abundant nicotinic receptor in the brain and it's the focus of my dissertation project. This receptor is involved in learning, memory formation, mood, attention and reward. Its dysfunction has been linked to …
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Searching for structural determinants of agonist selectivity in nicotinic acetylcholine receptors
The α4β2 and α7 receptors are the most abundant nicotinic acetylcholine receptors (nAChRs) in the brain, where they contribute to cognition, reward, nociception and mood. They are also implicated in depression, schizophrenia, cognitive deficit and in addiction to nicotine (Nic). Activation of these …
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The role of high affinity nicotinic acetylcholine receptors on anxiety-like behavior: a study in female mice
… phenotype. These results implicate α4β2*nAChRs and α6β2*nAChRs in anxiety-like behavior.</p>
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Heterologous Expression of Alpha 6*- Nicotinic Acetylcholine Receptors and the Natural Distribution of Alpha 6 Subunits
… α6β4, α6β2β3, α6β4β3, α6β2β3α5, α6β4β3α5, α6α4β2β3 and α6α4β4β3). The α6α4β2β3 combination may have a functional response to epibatidine that differs from that of the α4β2 nAChR. A unique binding site was identified in cells transfected with the α6β4β3α5 nAChR subunit combination. Messenger …
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Cytisine concentration-effect relationships in human smokers
… plant alkaloid that is a partial agonist for the α4β2-nicotinic acetylcholine receptor and is used as a smoking cessation medication (Tabex®). Double-blind, randomised, placebo-controlled trials show that cytisine is more effective than placebo in achieving long-term, continuous abstinence from …
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The effect of dietary neonicotinoid supplementation on innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus
… predominant nAChR in the mammalian brain is the α4β2 subunit that is resistant to α-BT but the α7nAChR, which is expressed at much lower levels and has been characterized on immune cells, is α-BT sensitive. Activation of nAChRs can initiate the cholinergic anti-inflammatory pathway (CAP) that has …