Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"α1 subunit"”.
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Direct Inputs to off Α and G9 Ganglion Cells From Aii Amacrine Cells In Rabbit Retina
… were marked with an antibody against the α1 subunit. This material was analyzed by triple-label confocal microscopy. We found the lobules of AIIs made close contacts at many points along the dendrites of individual OFF α and G9 ganglion cells. At these potential synaptic sites, we also …
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Investigation Of Whether Sedentary And Physically Active Conditions Lead To Altered Gabaergic Signaling In The Rvlm
… the RVLM. In order to investigate GABAA receptor α1 subunit expression on RVLM spinally projecting neurons, Sedentary (n=3) and physically active (n=4) male Sprague-Dawley rats were injected bilaterally with cholera toxin B (CTB) at spinal cord segment T9/T10. Double immunofluorescent labeling …
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Effects of Whisker-Trimming on GABAA Receptors in S1 Cortex
… (P<0.001) in layer 4. Altered levels of GABAA α1 subunit (Fritschy et al., 1994) were indicated by reduced optical density of immunostaining, both in deprived layers 2/3 (6.4% ± 0.7; P< 0.001) and in layer 4 (3.4% ± 1.0; P < 0.005). Interestingly, Nissl staining density also decreased in …
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Dilations of the Endoplasmic Reticulum Contribute to Spongiform Degeneration and Unlock a Door to a Unified Model of Neuropathological Features in Prion Diseases
… to neurons in mice expressing a humanized NKA α1 subunit. We further demonstrate that stressors, such as NKA α subunit overexpression and toxins triggering the unfolded protein response (UPR), cause profound ER dilation, particularly in the perinuclear space (PNS). Our pharmacological and …
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Compromising the 20S Proteasome Activates a Quality Control Pathway to Mitigate Proteotoxic Stress
… response. To my surprise I identified a core 20S subunit of the proteasome, α1 subunit. This finding uncovered its functional interaction with a yet uncharacterized regulator of proteasome stability in Drosophila, Ecm29 (CG8858). Whereas much is known of proteasome stress response at the level of …
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Functional characterisation of aphid, Myzus persicae, nicotinic acetylcholine receptors and identification of a novel biogenic amine-gated ion channel from the honeybee, Apis mellifera
… global pest of multiple crop species. The nAChR subunits and several protein chaperones from Myzus persicae have been cloned. It was difficult to achieve robust and frequent expression of a nAChR consisting entirely of subunits from Myzus persicae with the chaperones RIC-3, UNC-50 and TMX3. …
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Investigating the early events in proteasome assembly
… the process, prior to the involvement of the β subunits. A significant feature of proteasome assembly is the property of proteasomal subunits to self-assemble. While archaeal α and β subunits from Thermoplasma acidophilum can assemble into entire 20S units in vitro, certain α subunits from …
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The Characterisation Of Bee Nicotinic Acetylcholine Receptors
… Through the use of the Drosophila melanogaster α1 chimera + Gallus gallus β2 nAChR expressed in the Xenopus oocyte expression system and two-electrode voltage-clamping we show that species-specific target site variation in the α1 subunit between three species of bees (Apis mellifera, Bombus …
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PURINERGIC TRANSMISSION IN MIGRAINE: ROLE OF P2Y RECEPTORS IN THE SPINAL-TRIGEMINAL SYSTEM IN VIVO AND IN VITRO
… migraine type 1 (FHM1), was introduced in the α1 subunit of CaV2.1 calcium channels by a gene targeting approach (van den Maagdenberg et al., 2004). While there was no difference in BK-induced P2Y receptor upregulation in SCGs, between from wild type and CaV2.1 α1 R192Q mutant KI cultures, a …
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Repeated Zolpidem Treatment Effects on Sedative Tolerance, Withdrawal, mRNA Levels, and Protein Expression
… is necessary due to the ongoing usage of subunit specific GABAAR PAMs and, to a broader extent, an understanding of GABAARs themselves. </p> <p>In Study 1, we measured sedative tolerance, cross-tolerance, and GABAAR associated mRNA levels in 4 regions of interest (ROI; the cortex, …