Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"α-synuclein"”.
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The functional and pathological pathways of α-Synuclein
… aggregation of intrinsically disordered α-Synuclein (αS) is associated with Parkinson’s disease (PD) and other neurodegenerative diseases termed synucleopathies, whereby αS aggregates are a major constituent of Lewy bodies, a hallmark of these diseases. Despite the apparent link between αS …
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α-Synuclein phosphorylation and related kinases in Parkinson’s disease
… pathologies largely made from insoluble α-synuclein phosphorylated at serine 129 (S129P). Several kinases have been suggested to facilitate α-synuclein phosphorylation in PD, but without significant human data the changes that precipitate such pathology remain conjecture. The major aims of …
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Solid-state NMR studies of α-synuclein fibril structure
… disease (PD). Their primary protein component, α-synuclein (α- syn), adopts an amyloidogenic fibrillar form in Lewy bodies. In recent years research has slowly started to unravel clear pathological links between this fibrillar protein and PD disease progression. While great progress is being made, …
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Regional Lysosomal Malfunction Underlies the Selectivity of α-Synuclein Neurodegeneration
… pathway results in distinct pathologies. α-Synuclein is a protein whose aggregation and oligomerization has been implicated in several diseases, including Parkinson’s disease (PD). Herein, we investigated regionally selective alterations in α-synuclein degradation to decipher potential …
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Structural Properties of α-Synuclein in Functional and Pathological Contexts
α-synuclein (αS) is an intrinsically disordered protein that is strongly connected with Parkinson’s disease (PD) and a number of other neurodegenerative disorders, including Parkinson’s disease with dementia, dementia with Lewy bodies and multiple system amyotrophy. Fibrillar aggregates of αS have …
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Development of single-molecules techniques to study native α-Synuclein aggregates
It is now widely recognised that α-Synuclein (αSyn) oligomers are the main pathogenic species in Parkinson’s Disease (PD). In addition to being cytotoxic they are also thought to play a central role in the interneuronal spread of αSyn pathology. There is compelling evidence to suggest that these …
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Oxysterols in Neurodegeneration and the Influence of Presynaptic α-Synuclein Phosphorylation
… dysfunction, with a specific focus on alpha-synuclein (aSyn), a presynaptic protein centrally involved in PD pathology. Biophysical analyses revealed that both 24S-HC and 27-HC bind directly to aSyn with higher affinity than cholesterol. Interestingly, despite this binding, 27-HC does not …
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A deep dive into the liquid droplet state of α-synuclein
… aggregates primarily composed of misfolded α-synuclein. Despite extensive research, the precise relationship between α-synuclein aggregation and Lewy body formation remains elusive. This study investigates the dynamic process of α-synuclein aggregation, shedding light on its transition from …
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Investigating the Potential Role of α-Synuclein in Tau Aggregation and Toxicity
… of intracellular abnormal aggregation of α-Synuclein (α-Syn) in Lewy bodies (LBs) and Lewy neurites (LNs), are collectively known as synucleinopathies. Even so, tau protein pathology is abundantly found in these diseases. Apart from Parkinson’s disease (PD), dementia with Lewy bodies (DLB) …
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Oligomer dynamics for drug discovery against α-synuclein aggregation in Parkinson's disease
The aberrant aggregation of α-synuclein in Parkinson’s disease and related synucleinopathies is a histological hallmark of these conditions, as well as a cytotoxic process with no known disease-modifying interventions. While many studies have sought to develop small molecules or other biologics …
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Structural studies of the in vitro assembly of tau and α-synuclein amyloids
… revealed that specific conformers of tau and α-synuclein are associated with different diseases. These findings suggest that specific molecular mechanisms underlie the formation of filaments in the different diseases. However, studying the molecular mechanisms of amyloid assembly in *post …
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Propagation of Oligomeric α-Synuclein and Amyloid-β: Implications for Parkinson's and Alzheimer's Diseases
… disease (PD). The proteins <strong>α</strong>-synuclein (<strong>α</strong>S) and amyloid-<strong>β </strong>(A<strong>β</strong>) are involved in the formation of amyloid lesions observed in PD and AD, respectively. Both PD and AD exhibit a significant amount of co-pathology in clinical …
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Intracellular peptide library screening to derive inhibitors of Parkinson's disease associated α-synuclein aggregation
Aggregation of α-synuclein (α-syn) into toxic fibrils is a pathogenic hallmark of Parkinson’s disease (PD). This research aimed to develop peptides capable of inhibiting α-syn aggregation using a semi-rational design combined with a multiplexed intracellular Protein-fragment Complementation Assay …
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Exploration of a liquid droplet state for α-synuclein in vitro and in vivo
… protein misfolding and aggregation. Misfolded a-synuclein is a major constituent of intracellular inclusions called Lewy bodies, which are a key hallmark of PD. A large body of work shows that a-synuclein can self-assemble into amyloid fibrils via a nucleation dependent pathway. However, the …
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Revelation of new properties of pro-apoptotic human proteins, Bax and α-synuclein, using baker's yeast
… post-mitotic cells such as neurons. Bax and α-synuclein are two human proteins which play a role in the induction of neuronal apoptosis in neurodegenerative diseases like Alzheimer’s and Parkinson’s. Human Bax and α-synuclein also induce cell death when expressed in baker’s yeast, Saccharomyces …
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Non-toxic concentrations of α-synuclein exacerbate Parkinson's disease-like cell death by inducing mitochondrial dysfunction
α-Synuclein (α-syn), is a self-aggregating protein that has been identified as a pathologically important component in a number of diseases, such as Parkinson’s disease (PD). PD, a progressive neurological disorder affecting 1 in 500 people, results in motor dysfunction following the loss of …
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