Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"α-ketoamide"”.
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Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism
… for the design of three classes of compounds: ketoamide, ketone, and reduced amide analogues. Specifically, a convergent synthesis of α-ketoamide inhibitors of Pin1 was developed. An α-hydroxyorthothioester derivative of Ser was reacted directly with an aminyl synthon. The reaction was …
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New chemical and biosynthetic methodologies for the study of lanthipeptides
… after leader peptide removal results in α-ketoamides that site-specifically react with an aminooxy-derivatized alkyne or fluorophore. The fluorescently-modified lantibiotics were added to bacteria, and their cellular localization was visualized by confocal fluorescence microscopy as a means …