Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"α-glucosidase"”.
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Development, evaluation, and In-vitro assessment of artificial intelligence antidiabetic predictive models from α-glucosidase inhibitors
… accounting for over 90% of cases. Intestinal α-glucosidase enzymes, located at the small intestine's brush border, are important treatment targets in T2DM as they are involved in the terminal point of carbohydrate digestion in the gut, liberating glucose molecules, which are then transported …
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Grape Extracts for Type 2 Diabetes Treatment Through Specific Inhibition of α-Glucosidase and Antioxidant Protection
… rich antioxidant grape extracts (GE) on α-glucosidase inhibitory activity in vitro and in vivo blood glucose control, oxidative stress, and inflammation associated with obesity-induced type 2 diabetes. Because intestinal α-glucosidase plays a key role in the digestion and absorption of …
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Proteinaceous inhibitors of α-amylase and α-glucosidase from common bean (Phaseolus vulgaris L.): biochemical characterization and phylogenetic analysis of Sardinian cultivars
… proteinaceous α-amylase inhibitors (α-AIs) and α-glucosidase inhibitor could play an important role in weight loss and control of glycemic index above all in overweight and diabetic subjects. In this study 10 poorly studied Italian P. vulgaris cultivars were screened about their content in …
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Anti-Diabetic and Anti-Obesity Activities of Cocoa (Theobroma cacao) via Physiological Enzyme Inhibition
… oxidative polymers, and abilities to inhibit α-glucosidase, pancreatic α-amylase, lipase, and dipeptidyl peptidase-IV (DPP4) in vitro were compared between unfermented bean (UB), fermented bean (FB), unfermented liquor (UL), and fermented liquor (FL) cocoa extracts. Overall, there were …
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Synthesis of Glitazone Analogues as Anti-Diabetic Drugs
… for their inhibitory activities against α-glucosidase and α-amylase. Among all the synthesized compounds, 36f exhibited excellent antidiabetic activities against α-glucosidase. Compounds 36a, 36b, 36i and 36j also displayed good activities and have potential to be further investigated …
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Antioxidant and antihyperglycemic potential of soybean hydrolysates
… of peptides with potent AC as well as α-glucosidase and α-amylase inhibitory activities. Nine protein-based beverages and ten functional ingredients (I-5 to 14) were analyzed for their AC and starch-hydrolyzing enzymes inhibitory activity. Four beverages and four protein-based ingredients …
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Isolation and characterization of antidiabetic constituents of Bridelia Micrantha
… exhibited high inhibition activity against α-glucosidase (98.52, 98.62 and 81.62% respectively). A moderate inhibition against α-amylase enzyme was observed for root (65.62%) and stem (61.86%) extracts. Leaf fraction LFR5 exhibited a high inhibition activity of 96.19% against α-glucosidase. …
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Synthesis of sulfonylthioureas as anti-diabetic drugs
… discussed the synthesis, cytotoxicity and alpha-glucosidase inhibition of sulfonamides and novel sulfonylthiourea compounds. Three series of novel sulfonylthiourea [benzamido-benzenesulfonylthiourea (28a-28d), pyrrolidino-benzenesulfonylthiourea (33a-33c) and acetamido-benzenesulfonylthiourea …
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In vitro evaluation of the enzyme inhibition and membrane permeation properties of benzophenones extracted from honeybush
… the enzyme inhibition (i.e. lipase and α-glucosidase) effect of crude honeybush extracts, benzophenone rich fractions and xanthone rich fractions from Cyclopia genistoides. The in vitro permeation of marker molecules (i.e. benzophenone and xanthone molecules) after application of the crude …
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Physico-chemical and therapeutic properties of low-fat yogurt as influenced by fat replacers, exopolysaccharides and probiotics
… based on their proteolytic, ACE-inhibitory and α-glucosidase inhibitory activities; b) to study the influence of a fibre-based fat replacer (Raftiline HP) and a protein-based fat replacer (Versagel) on the growth, proteolytic, ACE-inhibitory and α-glucosidase inhibitory activities of selected LAB; …
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Evaluation of the antioxidant and anti-diabesity potential of cyclopia maculata using in vitro non-cell based screening models
… of the inhibition of the digestive enzymes, α-glucosidase and pancreatic lipase
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In vitro and in vivo effects of sorghum condensed tannins encapsulated in kafirin microparticles on digestive amylases
… condensed tannins (SCT) inhibit α-amylase and α-glucosidase enzymes. However, orally administered SCT may have poor inhibitory action against amylases, due to non-specific protein binding. Research is required to determine how to effectively deliver SCT to the small intestine to inhibit digestive …
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Determination of the in vitro antidiabetic potential of a polyherbal commercial tea
… activity was assessed against α-amylase and α-glucosidase activity using 3,5-dinitrosalicylic acid (DNSA) and p-nitrophenyl-α-D-glucopyranoside (p-NPG), respectively. The type of inhibition exerted on these enzymes was determined using the Michaelis-Menten enzyme kinetics model, expressed as …
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In vitro starch digestibility and ex-vivo glucose response studies of Vietnamese starchy foods using Caco-2 cells and 14C radioisotope
… before being subjected to measuring α-glucosidase, glucose uptake and transport. Digestibility of rice starch with amylose contents ranging from 0.2-28.4% was independent of physicochemical properties when cooked in limited water. Vietnamese cooked white rice was high in RDS (82.5%) but …
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Characterization of blackcurrant berries (Ribes nigrum) and the evaluation of their bioactive compounds after ultrasound-assisted water extractions, enzymatic treatments, and fermentation
… their effect on the activities of α-amylase, α-glucosidase, DPPIV, as biochemical markers of diabetes. In addition, the antioxidant capacity was measured using 2,2- diphenyl-1-picrylhydrazyl (DPPH·), after water-based ultrasound assisted extraction, treatment with pectinase and fermentation. BC …
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Genome Sequence Analysis and Characterization of Recombinant Enzymes from the Thermoacidophilic Archaeon Picrophilus torridus
… verwendet. Zwei rekombinante Enzyme, eine α-Glucosidase (MalP) und eine Glucose-1-Dehydrogenase (GdhA), wurden produziert, aufgereinigt und biochemisch charakterisiert.
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Evaluation of cocoa (Theobroma cacao) bean processing strategies to enhance alpha-glucosidase inhibitory activity of dietary cocoa
… (mDP). All CPEs dose-dependently inhibited α-glucosidase enzyme activity, with cool fermented/cool roasted cocoa powder exhibiting the best inhibition (IC50 of 62.2 µg/mL). Increasing flavanol mDP was correlated with decreasing IC50 values, suggesting that the complex flavanols produced during …
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Influence of dietary polyphenols on carbohydrate intestinal digestion and absorption
… to inhibit carbohydrate digestion (amylase and glucosidase) and (2) polyphenolic inhibition of intestinal glucose transport. While the high potential of these activities is evident, little is actually known regarding the extent to which these benefits are extendable to the actual food matrix …
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Evaluation of six plant species used traditionally in the treatment and control of diabetes mellitus
… (carbohydrate digestive enzyme) activity, alpha glucosidase (glucose absorption) activity and islets of Langerhans insulin secretory activity. Hexane, ethyl acetate, acetone and methanol extracts were examined and screened for their phytochemical properties and activity in the selected assays …
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ENZYMATIC PRODUCTION OF PURIFIED ISOMALTOOLIGOSACCHARIDES PREBIOTIC PREPARATIONS AND THEIR FULL QUALITATIVE AND QUANTITATIVE CHARACTERIZATION
… families (a glucosyl-transferase and an α-glucosidase) were tested on maltose individually or in combination. The IMO kinetics of formation and mixtures obtained were compared with a view to produce IMO preparations with singular profiles. Finally, a new original method was set up to …
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