NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 8 of 8 for “"α-amanitin"”.

  1. THE MECHANISMS OF α-AMANITIN RESISTANCE IN THE FRUIT FLY DROSOPHILA MELANOGASTER

    Mitchell, Chelsea L

    mtu Repository record

  2. DUPA α-Amanitin Conjugates for Targeted Prostate Cancer Therapy - Optimization and Evaluation of In Vivo Potency

    Korsak, BarbaraUniversität Bielefeld

    … its conjugation to a cytotoxic payload α-amanitin which is the inhibitor of RNA Polymerase II. The inhibition of RNA Polymerase II represents a completely new mode of action distinct to other toxins currently used for ADCs and SMDCs development. The most potent DUPA-α-amanitin conjugates …

    bielefeld Repository record

  3. Balancing Antitumor Efficacy and Safety Profile: α-Amanitin-Based Fc-Small Molecule Drug Conjugates for Targeted Prostate Cancer Therapy

    Carraturo, DanielaUniversität Bielefeld

    … cells, Fc-fragment for half-life extension, and Amanitin as a toxin bearing a cleavable linker. This conjugate showed good in vivo efficacy; however, because of the low tolerability, the therapeutic index (TI) was low (=1). To increase the tolerability, this work focused on the unspecific uptake …

    bielefeld Repository record

  4. α-Amanitin-based Small Format-Drug Conjugates for Prostate Cancer Therapy: Enabling Anti-Tumor Activity by Tuning Pharmacokinetic Properties

    Gallo, FrancescaUniversität Bielefeld

    … target of virtually all prostate cancers. α-Amanitin, a natural toxin isolated from the green death cap mushroom Amanita phalloides, which acts as potent RNA polymerase II inhibitor of eukaryotic cells, was investigated as innovative SMDC drug payload. Variation of the linker and conjugation …

    bielefeld Repository record

  5. Protein coding transcription and control of vsp gene expression in the protozoan parasite Giardia lamblia

    Seshadri, VishwasThe University of Arizona.2004

    … from these processes in higher eukaryotes. α-amanitin is a relatively selective inhibitor of eukaryotic RNA Polymerase II (RNAP II), and is commonly used to study RNAP II transcription. Therefore, we measured the sensitivity of G. lamblia RNAP II transcription to α-amanitin and found that …

    arizona-thes Repository record

  6. An Alternative View of the Templates and Functions of RNA Polymerase II

    Filipovska, Julija

    … transcription reaction is highly sensitive to α-amanitin in HeLa cell NE, but it is partially resistant to this toxin in NE from PMG cells that contain an α-amanitin resistant allele of the pol II largest subunit, strongly suggesting pol II involvement in the process. Direct RNase A, T1 and RNAse …

    rockefeller Repository record

  7. Understanding the relationship between large-scale chromatin structure and gene expression

    Groat, ElaineThe University of Edinburgh2022

    … Interestingly, in the presence of either α-amanitin, which inhibits transcription elongation, or triptolide, which inhibits transcription initiation, estrogen stimulation still caused cytological decompaction of the TFF1 locus, though the decompaction was delayed. The delay suggests …

    edinburgh Repository record

  8. Molekulare Analyse der mRNA-Expression von Plasma-Prokallikrein

    Neth, PeterLudwig-Maximilians-Universität

    … den Transkriptionsinhibitoren Actinomycin D, α-Amanitin und DRB zeigten, dass die mRNAAbbaurate in HepG2-Zellen vom jeweils eingesetzten Transkriptionsinhibitor abhängt. Bei allen Transkriptionsinhibitoren wurde das PPK-Transkript im Vergleich zu GAPDH deutlich schneller (Faktor 3-5) abgebaut. …

    lmu-germany Repository record