Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"α-Tertiary amines"”.
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The photoredox-catalysed generation and reaction of alkyl α-amino radicals for α-tertiary amine synthesis
… focused on the synthesis of α-trialkyl-α-tertiary amines, exploiting photo-reductively generated alkyl α-amino radicals as intermediates. The first project describes the development of a multicomponent method for the photoredox-mediated synthesis of α-trialkyl α-tertiary amines (ATAs). …
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Modular Methods for the Synthesis of α-Tertiary and α-Branched Alkylamines via Visible-Light-Mediated Radical Generation
… is a central goal of organic synthesis. Alkylamines are interesting synthetic targets because they occupy a privileged position in drug discovery yet are often highly challenging to synthesise. Complex alkylamines commonly feature branching at the α-position, which can further complicate their …
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New strategies for the synthesis and functionalization of aliphatic amines
… chemicals into pharmacologically-privileged amines is a landmark challenge in organic synthesis. This thesis describes the development of three novel transition-metal catalyzed processes for the synthesis of alkylamines that attempts to meet this challenge. The first Pd-catalyzed methylene …
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Palladium-Catalysed Carbonylation of Aliphatic Amines and its Application in the Total Synthesis of Cylindricine C
… C(sp3)–H carbonylation of secondary aliphatic amines. Chapter 2 describes the development of a general methyl C–H carbonylation of secondary aliphatic amines to form synthetically useful β-lactam building blocks. Amines exhibiting a range of substitution patterns around the nitrogen …
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Visible-light-mediated synthetic strategies for the synthesis of α-tertiary amine derivatives
The α-tertiary amine—a nitrogen atom with an α-carbon bearing three C–C bonds—is a motif that is widely prevalent in pharmaceutical materials and natural products. As a result of the fully substituted α-centre, compounds bearing this fragment have a high degree of structural complexity. This …