Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"α-Galactosylceramide"”.
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Uncovering Novel Mechanism of Immune Modulation of Invariant Natural Killer T Cells By Liposomal Α-Galactosylceramide
… sponge, <em>Agelas mauritianus</em>, alpha-Galactosylceramide (α-GalCer) potently activates iNK-T cells. Within a few hours after activation, iNK-T cells produce high quantities of T<sub>H</sub>1 and T<sub>H</sub>2 type cytokines, thus shape subsequent adaptive immunity towards inflammation …
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Characterisation of the immunomodulatory properties of human natural killer T cells
… when stimulated with the iNKT cell agonist α-galactosylceramide (αGalCer) in murine models. However iNKT cell based immunotherapies have proved disappointing in phase I and II clinical trials to date. Humans have a wider repertoire of CD1-restricted T cells compared to mice. These CD1 …
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Lipid antigens and immunoregulatory iNKT cells in the prevention and treatment of type 1 diabetes and related autoimmune diseases
… and presentation of lipid antigens such as α-galactosylceramide (α-GalCer) to iNKT cells, producing a variety of anti-inflammatory (T\(_H\)2) cytokines, such as interleukin-4 (IL-4), and pro-inflammatory (T\(_H\)1) cytokines, such as interferon-γ (IFN-γ). A decreased number of iNKT cells and …