Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"α-Cell"”.
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Paracrine control of glucagon secretion in the pancreatic α-cell: Studies involving optogenetic cell activation
… mechanisms controlling glucagon secretion by α-cells in islets of Langerhans were studied. We generated mice with the light-activated ion channel ChR2 specifically expressed in β-, α-, and δ-cells, and explored the spatio-temporal relationship between cell activation and glucagon release. In …
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Regulation of glucagon secretion from pancreatic alpha cells
Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. Like …
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Regulating Distinct Cell Lineages in the Pancreatic Islet
… with a loss of functioning insulin-producing β cells in the pancreas. Understanding the mechanism of normal islet and β cell development will be an important step in developing possible treatments for the disease. Nkx2.2 is essential for proper β cell differentiation. Nkx2.2 mice show a complete …
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Regulation of TNF-alpha gene expression by TNFAIP1 as an activator or suppressor in response to lipopolysaccharide
… experiments including: A culture of mouse RAW cells and human THP-1 cells in RPMI media supplemented with 10% FBS at 37°C in 5% CO2, Polymerase Chain reaction (PCR) using specifically designed primers and DNA cloning of TNFAIP1, transfection of the cloned TNFAIP1 cDNA into macrophages, Western …
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Transcriptomic analysis of pancreatic cells in zebrafish
… the metabolism of all vertebrates. The endocrine cells are mainly grouped into the islets of Langerhans and secrete distinct hormones, such as glucagon (α-cell), insulin (β-cell), somatostatin (δ-cell) and ghrelin (ε-cell). Diabetes occurs when insulin production by the β-cells is unable to …
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VERTICAL SLEEVE GASTRECTOMY IMPROVES GLUCOSE HOMEOSTASIS VIA [beta]- CELL GLUCAGON-LIKE PEPTIDE-1 RECEPTOR SIGNALING BUT PROMOTES COLITIS DEVELOPMENT IN MICE
… this model we have investigated the role of β-cell glucagon-like peptide-1 receptor (GLP-1R) signaling in the glucoregulatory benefits of VSG and have also explored the effect of VSG on colitis development. One of the most remarkable changes seen after VSG is high rates of type 2 diabetes …
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Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function
… or dysfunction of pancreatic insulin producing β cells or development of insulin resistance. In Type 1 diabetes β cells are destroyed in the process of an autoimmune attack, whereas in Type 2 diabetes, islets produce insufficient amounts of insulin or the insulin cannot be used adequately. So far, …