Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid"”.
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Structural and Functional Effect of Phosphorylation On Ampa Receptors
… Vasanthi Jayaraman, Ph. D.</p> <p>The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor is the primary contributor to neuronal fast excitatory transmission, and plays a key role in learning and memory. Previous studies have established that residues S818, S831, and T840 …
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Neuropathological significance of PLD1 in Alzheimer's disease and behavioral variant frontotemporal dementia
… that bvFTD patients exhibited reduction in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits; GluA3 and A4, that may contribute to the observed deficits in FASS-LTP. This dissertation provides its readers with valuable insights into the neuropathological …
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NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation
… of fear is dependent upon activation of N-methyl-D-aspartic acid receptors (NMDARs). Stimulation of NMDARs recruits neuronal nitric oxide synthase (nNOS) to the synaptic scaffolding protein, postsynaptic density protein 95 (PSD95), to produce nitric oxide (NO). Our laboratory has previously …
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Regulation of AMPA receptor acetylation and translation by SIRT2 and AMPK: the molecular mechanisms and implications in memory formation
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are ligand-gated glutamatergic ion channels that mediate most excitatory neurotransmission in the brain. Alterations in AMPAR synaptic accumulation mediate synaptic plasticity, including long-term potentiation, long-term …
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The effect of propofol on α‐amino‐5‐methyl‐4‐isoxazole propionate(AMPA) induced neurotoxicity in rat mixed cortical cultures
… overstimulation of glutamate receptors such as Nmethyl- D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainite. The pattern of AMPA mediated neurotoxicity (necrosis vs apoptosis) and the neuroprotective effect of propofol to AMPA mediated neurotoxicity still …
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Investigating the Molecular Function of APP Interacting Proteins in Synaptic Neuromodulation
… we examined the interactions of CNTN4 with α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid glutamate receptors (AMPARs), which mediate fast excitatory synaptic transmission and are often dysregulated in neurological disorders. Finally, we examined whether epigenetic methylation changes …
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Generation of a CRISPR-Cas9 mediated knock-in reporter for the GRIA3 candidate gene for schizophrenia
… candidates for the condition. A study on α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor genes found strong evidence of association between the Glutamate Ionotropic Receptor AMPA Type Subunit 3 (GRIA3) gene and SZ. Similarly, a recent report has identified a number of …
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Metabolic and functional approaches to investigate the effects of cytokines on the physiology of in-vitro and in-vivo models of diabetic retinopathy
… channel permeability in DR. Activation of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor but not the other ionotropic receptors, resulted in increased cation permeation into amacrine and ganglion cells in DR conditions, suggesting that these cells are specifically …