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Showing 1 to 20 of 3610 for “"α"”.
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Synthesis and reactivity of α-diazosulfoxides and α-diazosulfones
The focus of this body of work has been the synthesis of stable mono and bicyclic α-diazosulfoxides and their subsequent reactivity. A range of α-diazosulfoxides have been synthesised by the Maguire-Collins research group since the mid-1990s using a Regitz diazo transfer method. In this work in …
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Quinone-Catalyzed Amine α-C–H and α-C–C Functionalization
Amines are extremely useful compounds with diverse applications in multiple disciplines. For this reason, a myriad of synthetic methods has been developed for the preparation of amine compounds. Despite this, the majority of well-established methodology for amine synthesis relies on the …
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Roles of MoFe protein α-274-histidine, α-276-tyrosine and α-277-arginine residues in Azotobacter vinelandii nitrogenase catalysis
Previous studies revealed that α-275-Cys provides an essential ligand to one of the Fe atoms on the FeMo-cofactor, and its substitutions resulted in inactive nitrogenase. In order to study the structural-functional relationship of the protein environment in this region with respect to the …
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The Synthesis of α-Tocopentaenol (αT5), a Fluorescent Analogue of α-Tocopherol
This thesis is focused on the investigation of synthesizing a fluorescent analogue of vitamin E, α-tocopentaenol (αT5). α-Tocopentaenol contains five conjugated double bonds across the phytyl tail, resulting in its fluorescence characteristics. Different methodologies of preparation were attempted …
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Mechanism of tocopherol transfer by human α-tocopherol transfer protein (α-hTTP)
Vitamin E is a well known fat soluble chain breaking antioxidant. It is a general tenn used to describe a family of eight stereoisomers of tocopherols. Selective retention of a-tocopherol in the human circulation system is regulated by the a -Tocopherol Transfer Protein (a-TIP). Using a …
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Fumarate Inhibits TNF-α Release
<p>Vertebrates utilize two forms of immunity to combat pathogens. Innate immunity is considered the first line of defense that utilizes immediate action and three barriers. Innate immunity responses typically occur within minutes of pathogen exposure resulting in cellular receptor activation and …
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Α-ΦΕΤΟΠΡΩΤΕΙΝΗ ΚΑΙ ΣΥΓΓΕΝΗΣ ΥΠΟΘΥΡΕΟΕΙΔΙΣΜΟΣ
A-FETOPROTEIN (A-FP) WAS MEASURED IN DRIED BLOOD SPOTS TAKEN BY HEEL PRICK FROM525 NORMAL, 77 HYPOTHYROID AND 213 TRANSIENT HYPERTHYROTROPINAEMIC (TH) NEONATES. THE BLOOD SPOTS WERE COLLECTED AT THE TIME THE NEONATES WERE DISCHARGED FROM THE MATERNITY UNIT, I.E. BETWEEN 3RD AND 7TH DAY OF LIFE. …
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Biotin synthesis in α-proteobacteria
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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Synthetic Methods for the Preparation of 1,3-S,O-Esters, α-Phosphonovinyl Triflates, and α-Alkynylphosphonates
<p>A broad and systematic study was conducted on synthetic methods to efficiently synthesize 1,3-<em>S</em>,<em>O</em>-esters, α-phosphonovinyl triflates, and α-alkynylphosphonates under mild reaction conditions. The master’s thesis is composed of two projects; the first project is titled …
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Απομόνωση και δομή προθυμοσίνης α αιγός και συμβολή στη διερεύνηση της βιολογικής δραστικότητας της προθυμοσίνης α
The primary sequence of goat prothymosin a exhibits a high degree of homology to the sequences of prothymosin a from the other mammalian species. The highest levels of prothymosin a are found in thymus and spleen, with significantly lower levels in non-lymphoid tissues. During development, the …
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The photoredox-catalysed generation and reaction of alkyl α-amino radicals for α-tertiary amine synthesis
This thesis comprises three projects focused on the synthesis of α-trialkyl-α-tertiary amines, exploiting photo-reductively generated alkyl α-amino radicals as intermediates. The first project describes the development of a multicomponent method for the photoredox-mediated synthesis of α-trialkyl …
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Heterologous production of recombinant peptidylglycine α-amidating monooxygenase for the production of biosimilar α-amidated peptides
A biological method for peptide synthesis provides increased production capacity of inexpensive peptide pharmaceuticals with environmentally safe procedures relative to current chemical peptide synthesis. Most precursor peptides are readily produced from yeast and bacterial systems using …
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ΕΡΜΙΤΙΑΝΗ ΔΙΑΦΟΡΙΚΗ ΓΕΩΜΕΤΡΙΑ ΣΕ /Α-ΔΕΣΜΕΣ
IN THIS WORK, WE FIRST DEVELOP METHODS OF DIFFERENTIATION SUITABLE FOR MAPPINGS BETWEEN TOPOLOGICAL A-MODULES, WHERE A IS A COMMUTATIVE LOCALLY M-CONVEX * -ALGEBRA WITH UNIT. THIS EXTENDS WELL-KNOWN METHODS OF DIFFERENTIATION ON TOPOLOGICAL VECTOR SPACES, SUCH AS FRECHET AND HYERS DIFFERENTIATION. …
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α-Formylations with Chiral Chloroiminium Salts
The synthesis of quaternary carbon centres is a challenging task in organic chemistry, and this is believed to be due to the significant amount of ‘steric crowding’ involved in the creation of a quaternary carbon centre. This thesis discusses the discovery and development of a new method for the …
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Priority arguments in α-recursion theory,
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mathematics, 1972.
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Novel synthetic methodology employing transition metal catalysed reactions of α-diazo-β-keto sulfonamides and α-cyano-α-diazoacetates; the impact of substituents on the reaction pathway
The central focus of this thesis is the reactivity of α-diazo-β-keto sulfonamides, α-cyano-α-diazoacetates and α-arylsulfonyl-α-diazoacetates employing rhodium and copper catalysts. While the α-diazo-β-keto sulfonamides were specifically designed to investigate rhodium- and copper-catalysed …
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Redução química e eletroquímica de α-halo-ésteres e α-halocetonas e seus acoplamentos a compostos carbonílicos
Reagentes organometálicos estão envolvidos em diferentes tipos de reações orgânicas que podem formar novas ligações C-C e assim servem de base para a construção de estruturas químicas mais complexas. Geralmente os reagentes organometálicos são preparados a partir de compostos halogenados e metais …
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Design and synthesis of components for optically active metal-organic frameworks (MOFs) and synthetic routes to diverse deuterium labelled α-diazoacetates, α-diazoacetamides, α-diazoketones, and the antibiotic azaserine
Metal-organic frameworks (MOFs) are porous crystalline solids that consist of metal nodes connected to organic linkers that assemble into one-, two- or three-dimensional frameworks. Among other applications they have recently found use in heterogeneous asymmetric catalysis. Since that time the …
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