Global ETD Search
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Showing 1 to 1 of 1 for “"Σύνδρομο Netherton"”.
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Generation and characterization of novel mouse models to validate the role of KLK5 protease in inflammation for pharmacological applications
… associated with rare diseases, such as the Netherton syndrome (NS). In NS epidermis, genetic deficiency of the LEKTI inhibitor of serine proteases results in unopposed activity of KLK5 (and other serine proteases), which promotes skin inflammation via activation of the PAR2-NF-κB-TNFα …