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Showing 1 to 8 of 8 for “"ΔNp63"”.
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Δnp63 Regulates A Complex Network of Target Genes In Limb and Epidermal Development
… domain (TAp63) and those lacking this domain (ΔNp63). Mice lacking p63 cannot form skin, have craniofacial and skeletal defects and die within hours after birth. These defects are due to the ability of p63 to regulate multiple processes in skin development including epithelial stem cell …
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Investigating The Roles of Δnp63 As A Suppressor of Migration, Invasion, and Metastasis
… are the key to focused on studying the role of ΔNp63 in cancer, a p53 family member known to be involved in epithelial development, microRNA biogenesis, and stem cell maintenance. Using the strength of <em>in vivo </em>mouse models, we found that ΔNp63 is capable of modulating tumor development …
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Investigating The Role of The P63 Isoform Δnp63 In Lung Stem Cell Populations and Lung Cancer
… lung adenocarcinoma and squamous cell carcinoma. ΔNp63 is known to regulate lung development but its role in lung cancer progression remains unclear. We utilized a ΔNp63-specific conditional knockout mouse model to determine ΔNp63’s role in lung progenitor cells and lung cancer. In vivo and in …
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Deciphering The Roles of Δnp63 In Regulating Epithelial to Mesenchymal Transition, Cancer Progression and Metastasis
… be categorized into two main isoforms, TAp63 and ΔNp63, which are expressed in different cellular compartments and have distinct functions in many biological processes. While the Flores laboratory identified TAp63 as a tumor and metastasis suppressor, the precise roles of ΔNp63 isoforms in …
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Investigating The Roles of The P63 Isoforms In The Microrna Biogenesis Pathway
… acidic transcription activation domain. The <em>ΔNp63</em> isoforms, lack the TA domain, but have a proline rich region critical for gene transactivation. To understand the functions of these isoforms, the Flores lab generated <em>TAp63</em> and <em>ΔNp63 </em>conditional knock out mice. Using …
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Investigating The Roles of P63 and P73 Isoforms to Therapeutically Treat P53-Altered Cancers
… <p>I have demonstrated that deletion of ΔNp63 or ΔNp73 in p53-deficient tumors mediates tumor regression through the upregulation of tumor suppressive isoforms, <em>TAp63</em> and <em>TAp73</em>. Upon loss of ΔNp63 or ΔNp73, TAp63 and TAp73 activate <em>IAPP</em> a metabolic regulator, …
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Die Interferenz des Tumorsuppressor-Homologen p63 mit dem kanonischen Wnt-Signalweg
… untersucht. Es wurde vorgeschlagen, dass ΔNp63α, die am häufigsten exprimierte p63-Isoform in epithelialem Gewebe, die β-Catenin-Menge und somit die kanonische Wnt-Aktivität durch die Inhibition der GSK3β-Kinase positiv beeinflusst. Im Rahmen dieser Arbeit wurde nach transienter …