Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Δ9-THC"”.
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Behavioral Mechanisms of Δ9-THC in Nonhuman Primates
… effects and cognitive consequences of Δ9-tetrahydrocannabinol (THC), the primary psychoactive constituent in marijuana, is critical for developing treatments in cannabis dependent patients. Despite the fact that marijuana is the most commonly abused illicit substance in the U.S., …
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Il Δ9-THC, componente principale della cannabis sativa, attenua la neurotossicità indotta dalla meth
… line of research have demonstrated that natural (Δ9-tetrahydrocannabinol, Δ9-THC) and synthetic cannabinoid CB1 receptor agonists exert neuroprotective effects in different models of cerebral damage, including excitotoxic injury [Deng X and Cadet JL, 2009; La Voie MJ, et al. 2004]. In this study …
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The Effects of Methanol and Isopropanol on the Chiral Separation of Dronabinol and Three Related Impurities: A 3 X 3 X 3 Factorial Design
The enantioseparations of Δ9-THC and Δ8-THC on amylose tris dimethylphenylcarbamate CSP was investigated using mobile phases containing 1-3% methanol with 1-7% IPA in n-heptane. A factorial design was used to study the main and interaction effects of these alcohols as measured by the retention …
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Studio degli effetti della pre-esposizione adolescenziale al Δ9-THC nell’autosomministrazione di eroina, in età adulta, in un modello animale di maggiore (ratti Lewis) e minore (ratti Fischer 344) predisposizione all’abuso.
… this study was to investigate the influence of Δ9-THC adolescence exposure on the addictive properties of heroin in LEW and F344 strain, during heroin self-administration (SA) in adulthood. Methods: On the 6th postnatal (PN) week rats were administered twice a day with increasing doses of Δ9-THC …
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Bio-behavioural evaluation of efavirenz and Δ9-tetrahydrocannabinol alone and in combination in rats with respect to psychosis and anxiety
… illicit substances (e.g. marijuana (containing Δ9- tetrahydrocannabinol (Δ9-THC), methamphetamine and/or heroin). This multi-drug cocktail is then either smoked or injected to produce a somnolent, euphoric sensation. The abuse profile and addictive properties of "Nyaope" increases the financial …
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Modificazioni neuronali nella via abenulo-mesencefalica durante l’astinenza da Δ9-tetraidrocannabinolo
… male Sprague-Dawley rats. In order to induce Δ9-tetrahydrocannabinol (Δ9-THC) dependence, rats were chronically treated with Δ9-THC (15 mg/kg, i.p.), or its vehicle, twice daily for 6.5 days. Administration of the cannabinoid antagonist SR141716A (5 mg/kg, i.p.) precipitated an intense …
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Lipid & surfactant based systems for improved delivery of poorly soluble APIs
… study, studies have been performed to formulate Δ9-THC into a sustained release tablet, using lipid matrices, for the treatment of chemotherapy induced nausea and vomiting (CINV). In the second study, LBDDS such as solid lipid nanoparticles were prepared for non-invasively enhancing the ocular …
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Diagnostic use of hair analysis for the detection of misuse of amfetamines and cannabinoids
… 3,4-Methylenedioxyethylamfetamine (MDEA), Δ9-tetrahydrocannabinol (Δ9-THC) and 11-nor-9-carbody- Δ9-tetrahydrocannabinol (Δ9-THC-COOH) compounds. The comparison of the efficiency of four different pre-treatment methods (enzymatic, alkaline, acid and methanol) to extract AF, MA, MDA, MDMA, …
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Optimization and Development of In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2
… 100 being cannabinoids. Of those 100 compounds, Δ9-THC has been determined as the primary constituent, which is also responsible for the psychoactivity associated with Cannabis. Along with Δ9-THC, cannabidiol has been studied in depth for its therapeutic effects. This has currently been the focus …
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Systemic Blockade of the Endocannabinoid System Alters Gene Expression and acquisition of a Hippocampus Dependent Learning Task
… has been established that the administration of Δ9-THC and other cannabinoid agonists results in disruptions in learning and memory (Sullivan, 2000). The ability of rimonabant to reverse memory deficits induced by cannabinoid agonists lead to the hypothesis that administering it alone could …
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La signalisation du recepteur cannabinoïde de type-1 et son role dans la regulation de la dynamique du lactate cerebral chez la souris en libre mouvement [Il recettore cannabinoide di tipo 1 nella modulazione delle dinamiche del lattato cerebrale in topi in libero movimento]
… di immobilità e dopo la somministrazione di Δ9-THC, suggerendo che l’attivazione dei CB1R modula la tempistica e la dinamica della regolazione del lattato in maniera circuito-dipendente. In parallelo, abbiamo indagato i meccanismi di segnalazione intracellulare alla base della regolazione del …
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Medicinal Chemistry of Cannabis and Cannabinoids
… and the isolation of a hitherto undescribed cis-Δ9-THC species. Through this thesis, we report significant real-world evidence for the case that cannabis and cannabis extracts behave as complex mixtures of physiologically active molecules, whereby their effects on receptors vary significantly …
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Effect Of CBD On D2 Dopamine Receptor And CB1 Cannabinoid Receptor Function And Localization
… a CB1 negative allosteric modulator of (−)-trans-Δ9-tetrahydrocannabinol (Δ9-THC). Interestingly, the ECS is linked to the main circuit thought to modulate reward signaling when taking substances of abuse, the dopamine (DA) pathway. The DA pathway contains dopaminergic cell bodies originating in …
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Enzymology of lipid metabolism by CYP2J2 as controlled by multiple-ligand binding events
… endocannabinoid metabolism. Particularly, Δ9-THC, the most psychoactive and often the most predominant cannabinoid in marijuana, potently shuts down endocannabinoid metabolism through a non-competitive model. In Chapter 5, we characterize a new class of endocannabinoids called endovanilloid …
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Estudios de efectos neurobiológicos del Δ9-tetrahidrocannabinol (THC) en modelos animales
… química de su principal compuesto activo, el Δ9- tetrahidrocannabinol (Δ9-THC) ( Mechoulam y Gaoni, 1965). Dicho hallazgo supuso el inicio para años de investigación fructífera, los cuales se encuentran resumidos en las referencias que se muestran en la tabla 1. Los compuestos cannabinoides …