Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Β-arrestin-2"”.
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Nicotine Sensitization in β-Arrestin 2 Knockout Adolescent Mice.
<p>ß arrestin-2 is a protein involved in signaling of D2 receptors and plays a mediating role in sensitization to psychostimulants and the opiate morphine. In this study, 3-4 week old BA-2 KO and wild type C57/B6 mice received nicotine tartarate (s.c, 0.5 mg/kg free base) for 7 or 14 consecutive …
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Activation of the Transient Receptor Potential Vanilloid-1 (TRPV1) channel mediates Extracellular Signal Regulated Kinase (ERK) phosphorylation via Beta-arrestin-2 signaling
… Recent work highlighted a possible role for β-arrestin-2, a scaffolding protein that mediates G-protein coupled receptor desensitization, in channel regulation. Interestingly, β-arrestin-2 also acts as a signaling scaffold for the MAPK (ERK1/2) pathway which was described as an important …
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Studies on Cellular Nutrient Responses and Protein Degradation
… mechanism induced by perceived starvation. The arrestin proteins can bind GPCRs to mediate their internalization or to facilitate downstream signaling. I tested the hypothesis that β-arrestin 2 might participate in regulation of mTOR activity and autophagy by amino acids. siRNA-mediated …
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Determining the Effects and Signaling Properties of β-Blockers in House Dust Mite-Driven Murine Models of Asthma
… and their inhibition of the β2AR- associated β-arrestin-2-ERK1/2 pathway. All our previous studies were conducted in ovalbumin-driven murine models of asthma. However, ovalbumin models have been criticized for lacking clinical relevance. To address the limitations of the ovalbumin models, we …
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MOLECULAR MECHANISMS UNDERLYING CLINICAL BEHAVIOR OF NEUROENDOCRINE TUMORS: STUDY OF NEW POSSIBLE BIOMARKERS PREDICTABLE OF PHARMACOLOGICAL RESISTANCE AND TARGETS
… more specifically focusing on G-proteins and β-arrestins DRD2-mediated signaling pathways in PitNETs and on somatostatin/cortistatin system in novel PanNENs cell models. Briefly, β-arrestin 2 has been highlighted as novel potential biomarker of pharmacological responsiveness to DAs, and that …
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Regulation and desensitisation studies on the nicotinic acid receptors
… Both HM74 and HM74A failed to interact with β-arrestin 2 or internalise in response to nicotinic acid. However, both receptors were phosphorylated in an agonist-dependent manner. HM74 but not HM74A was demonstrated to desensitise as result of prolonged nicotinic acid exposure. The importance of …
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Modulation and Ligand Selectivity of Mammalian Odorant Receptors
… of M3-Rs inhibits the recruitment of β-arrestin-2 to ORs, resulting in a potentiation of odor-induced response in OSNs. These results suggest a role for acetylcholine in modulating olfactory processing at the initial stages of signal transduction in the olfactory …
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Post-translational modifications regulate β2-Adrenoceptor signaling in cardiac myocytes
… to mediate the association of β2AR with β-arrestin 2/ phosphodiesterase 4D complexes to regulate cAMP signaling. In addition, we provide a new mechanism explaining β2AR coupling from Gas to Gai, which is agonist dose dependent and controlled by both PKA and GRK phosphorylation of the …
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Fusion Proteins as Selective Inducers of Constitutive Activity and Tools to Discriminate the Biased Signaling Profile of β2 Adrenoceptor Ligands
… the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway. Exploring each pathway separately remains a challenging task due to the dynamic nature of the receptor. Here, we fused the β2AR with its cognate transducers, Gαs and βarr2, using short linkers as a novel approach for …
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Signal transduction by the 5-HT2A receptor and its H452Y polymorphic variant
… desensitisation are explored. It is shown that β-arrestin 2 (β-arr 2) confers a decrease in H452Y-5-HT2AR-mediated PLC activity, despite having no significant effect upon wild-type 5-HT2AR responses. The H452Y-5-HT2AR variant is also shown, by GST-fusion protein studies, to bind β-arr 2 more …
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Fragmented maternal care programs altered pain vulnerability and aberrant responses to opioids
… receptors (MOP), delta opioid receptors (DOP), β-arrestin 2 (Barr2) and c-Src kinase are all components of the opioid signalling system, which to differing degrees have been implicated in pain sensitivity and the behavioural effects of opioids including analgesia, tolerance, hyperalgesia, …