Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"ß-Lactamase"”.
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Modellkomplexe für zinkhaltige Hydrolasen mit Schwerpunkt auf der ß-Lactamase
… Zwischenstufen im Katalyseprozess der ß-Lactamase untersucht. <br>Die Reaktionen von TpZnOH mit ß-Aminosäuren führten zu TpZn-ß-Aminosäurekomplexen, in welchen die Aminosäure nur über die Carboxylatfunktion an das Zinkion bindet. <br>Bei der Umsetzung von TpZnOH mit ß-Propiolactamen, …
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Characterization of the metallo-ß-lactamase from Pseudomonas aeruginosa, IMP-1.
… in microbes are a class of enzymes known as β-lactamases. These enzymes are effective in breaking down the most commonly prescribed antibiotics at present. This work investigates two separate metallo-β-lactamase enzymes, first IMP-1, which provides antibiotic resistance to Pseudomonas …
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Studies on the mode of action and beta-lactamase inhibitory properties of novel oxapenem compounds
… oxapenem compounds were evaluated for their ß-lactamase inhibitory and antibacterial properties. Two (AM-112 and AM-113) displayed intrinsic antibacterial activity with MICs of between 2 to 16µg/ml and 0.5-2µg/ml against Escherichia coli and methicillin-sensitive and -resistant Staphylococcus …
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Escherichia coli infection: mechanisms and rapid detection of resistance to the association of ß-lactams with ß-lactamase inhibitors, and impact of the Sars-Cov-2 pandemic on the morbidity and mortality of intra-abdominal infection
… MIC was tested using broth microdilution, and β-lactamase activity was determined in these isolates. Whole-genome sequencing (WGS) was performed to decipher the role of blaTEM and other genes associated with P/T-R. Changes in the outer membrane protein (OMP) profile were analysed using SDS-PAGE, …
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The Influence of ampC Expression and Penicillin Binding Protein Binding on the Variation of ß-lactam Induction Potential in Three Genera of Enterobacteriaceae
… organisms encode inducible, chromosomal AmpC ß-lactamases which can cause, if overproduced, resistance to all ß-lactams except the fourth generation cephalosporins and the carbapenems. The interaction of ß-lactams with penicillin binding proteins (PBPs) disrupts cell wall synthesis and in the …