Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"; Xanthines"”.
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Structural studies of organic crystals of pharmaceutical relevance. Correlation of crystal structure analysis with recognised non-bonded structural motifs in the organic solid state
… chalcones, cryptolepines, biguanides and xanthines. These selected systems were validated using functional group and molecular analysis and correlating them to the Cambridge Structural Database. Crystallization studies are done on these selected systems as well as exploiting those using …
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Design and synthesis of new potential anticancer agents and high-selective A2B antagonists
… of 1-alkyl-8-(piperazine-1-sulphonyl)phenyl xanthines as high-selective A2B antagonists. Even though the leading role of adenosine and their receptors in cancer pathogenesis were extensively documented, the high therapeutic potential of these compounds requires a wider analysis of their …
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Effects of drugs which alter blood cell deformability in circulatory shock produced by endotoxin
… between cardiac stimulation produced by the xanthines and protection against endotoxic shock. All three xanthines caused a dose-dependent increase in the heart rate and antagonized the bradycardia caused by endotoxin. However, only pentoxifylline and caffeine increased survival. Buflomedil …
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Modified Purines. Rearrangement Through 5-Substituted Purine Intermediates
… are analogues of N(9)-substituted guanines, hypoxanthines, and xanthines. Structures were established in this series (1) on the basis of precursors and routes of synthesis, infrared spectra, mass spectra, ('1)H and ('13)C nuclear magnetic resonance spectra, and X-ray crystallographic analysis of …
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DIETARY BIOACTIVES IN THE MODULATION OF METABOLIC, FUNCTIONAL AND AGING BIOMARKERS
… aging. In particular, dietary (poly)phenols and xanthines have gained attention for their potential benefits on several metabolic and functional biomarkers. However, the mechanisms are not completely understood and the evidence in humans are still scarce. The present Ph.D. thesis investigates the …
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LIGHT AND ELECTRICITY: POWERFUL TOOLS FOR NEW SUSTAINABLE STEREOSELECTIVE SYNTHESIS
… method developed for the fluoroalkylation of xanthines derivatives and other bioactive molecules. In addition, the perfluoro C-H functionalization of Pirimidine and Purine analogues is carefully detailed. Chapter 4.3 collects the main results of the previous chapter giving a concise …
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Anti-inflammatory and anti-colon cancer potential of yerba mate (Ilex paraguariensis St. Hilaire) bioactive constituents
… of constituents mainly caffeoyl derivatives, xanthines, flavonoids and triterpenoid saponins that have been associated with cancer prevention. However, which constituents of yerba mate are involved in the protective effects against colon carcinogenesis is not clearly understood. The objective …
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Phosphodiesterase 4 inhibitors for the treatment of inflammation associated with respiratory disease
… in vivo. The drug classes examined were xanthines, aryl sulphonamides, quinolones, 7-methoxybenzofuran-4-carboxamides, and 7-methoxyfuro[2,3-c]pyridine-4-carboxamides. The lead molecules selected in each publication had improved PDE4:RBA ratios which translated into an improved …