Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"; Signalling molecules"”.
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Multiscale Modelling and Analysis of Plant Cell Signalling Processes and Biomechanics
… are regulated by complex networks of interacting signalling molecules. Signalling pathways activate in response to external or internal cues, leading to a series of signalling processes which end with changes in gene expression. By modifying protein level in this way, specific signalling molecules …
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Molecular insights into signalling mechanisms within TGF-β superfamily
… superfamily includes receptors, extracellular signalling molecules, their inhibitors and intracellular downstream signalling components. Members of the superfamily are present in all metazoans, expressed in all cells of the body and they are involved in embryonic development, adult tissue …
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Quorum sensing for improved production of industrially useful products from filamentous fungi
… of low molecular weight, diffusible chemical signalling molecules, known as quorum sensing molecules (QSM) in the extracellular milieu. When the concentrations of the QSMs reach a critical threshold corresponding to a particular cell density, they bind to a receptor enabling them to function …
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Altering Inhibitory Extracellular Matrix Promotes Remyelination
… (CSPGs) are a family of extracellular matrix molecules that provide structural rigidity to tissues and act as signalling molecules to neurons and glia in the developing nervous system. After injury, CSPGs become highly upregulated by astrocytes as part of the glial scar and restrict axonal …
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Disruption of mitochondrial redox homeostasis as a cellular signal.
… components of eukaryotic cells and exchange signalling molecules, metabolites, proteins and lipids with the rest of the cell. The organelle is key for energy metabolism as they provide most of the cellular ATP through oxidative phosphorylation and regulate intermediate metabolism. …
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Cell-selective modulation of the neuromuscular system in Drosophila
… highly evolved, eukaryotic species, like humans, signalling mechanisms are necessary to regulate the function and survival of all cells in the organism. Synchronizing systemic signalling systems at the cellular, organ and whole-organism level is a formidable task, and for most species requires a …
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The effect of RAN inhibition on human colorectal cancer cells (CRC)
… identify expression levels of various genes and signalling molecules after treatment with 0.5 mM MBZ. In addition, several assays were performed to investigate MBZ effect on biological properties of the cells such as proliferation, migration, invasion, and colony formation. MBZ downregulated Ran …
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Molecular Sensing using Surface-Sensitised Plasmonic Nanogaps
… significantly enhance the Raman scattering of molecules located in metal nanostructures, enabling improved detection sensitivity. However, further development is essential to maximise signal enhancement and broaden the applicability of this technology. This thesis explores SERS sensing using …
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Investigating Anatomical and Neurochemical Topology of the Mammalian Suprachiasmatic Nucleus
… which are heterogeneous in their expression of signalling molecules, rhythmic properties and connectivity to one another. It is through emergent network properties that the diversity of cells is able to synchronise cell-autonomous rhythms and generate an ensemble signal that is conveyed to local …
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Central vasopressin signalling and aggressive behaviour
Although many signalling molecules appear relevant to the production of complex behaviours, those that are important to the physiological regulation of behaviour, and so those that characterise individual styles of behaviour, are unknown. Vasopressin is the strongest candidate regulator of social …
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Der Einfluss von Retinsäure auf die dorsoventrale Augenachse des Haushuhns
… receptors. Their action in turn is regulated by signalling molecules with spatially restricted expression domains in the dorsal (e.g. Tbx5, BMP4) and ventral eye cup (e.g. Pax2, cVax). To test whether RA influences the distribution of this signalling system, its concentration in the early chicken …
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Investigation of defence mechanisms against Botrytis cinerea in Arabidopsis thaliana
… research has shown that accumulation of 3 signalling molecules are vitally important for establishing a resistance response, as aberrant signalling or accumulation of salicylic acid , ethylene or jasmonic acid `leads to an altered resistance response. Researchers continue to isolate and …
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Investigating the host-microbe dialogue in aging
… The focus was maintained on key inter-kingdom signalling molecules, host produced but bacterially modified Bile acids (BAs) and on dietary microbially derived Fatty acids (FAs) as key elements to indicate gut microbial potential impactful roles. In the context of Chapter 3, this thesis examined …
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Mikrobielle Ökologie N-Acyl-L-Homoserinlacton-produzierender Bakterien in der Rhizosphäre von Tomatenpflanzen
N-Acylhomoserinlactones (AHL) are signalling molecules in gram-negative bacteria, which regulate, in a cell density dependent way, important interactive functions. This phenomenon is known as quorum-sensing. This work characterised the microbial ecology of the autoinducer (AHL) producing bacteria …
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The Role for Proteoglycans in Regulating Embryonic Patterning and Morphogenesis
… The activity and behaviour of these signalling molecules is regulated in the extracellular space through interactions with proteoglycans. Proteoglycans are high molecular-weight proteins consisting of a core protein with covalently linked glycosasminoglycan (GAG) sidechains, which are …
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The Role Of The DOMAIN OF UNKNOWN FUNCTION (DUF2358) In Sugar Signalling Pathways In Arabidopsis thaliana
Sugars play a key role as signalling molecules to regulate metabolism and development of plants but also play a critical role in response to abiotic stresses such as drought and high salinity . This study was conducted to investigate the role of DUF2358 in sugar signalling pathways under stress …
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The structure and function of TasA in the <i>Bacillus subtilis</i> biofilm matrix
… and abiotic stresses and to retain nutrients and signalling molecules. The multiple functions of the biofilm matrix are mediated by the constituent parts which may include a combination of complex polysaccharides, lipids, nucleic acids and proteins. Some of the proteins found within the matrix are …
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Sonic hedgehog induces Motor Neuron Differentiation in P19 Embryonic Carcinoma Cells
… (Shh) is a member of the hedgehog family of signalling molecules and secreted from two signalling centers, the notochord and the floor plate, where it functions as a morphogen to induce early dorso-ventral patterning of the cenral nervous system (CNS). More recently, multiple actions of Shh …
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The Integration of Metabolite and Hormone Signalling Drives Seedling Development
… plant biology, acting as structural components, signalling molecules, and sources of energy. As such, the availability of sugars has important implications for plant growth and development. Sugar levels rise and fall as part of a daily cycle, while cues from other environmental stimuli are also …
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