Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"; SUR2B"”.
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Investigations into the roles of potassium channels in hair growth. Studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approaches.
… KATP channels has three forms: SUR1, SUR2A and SUR2B which all respond to different molecules. Minoxidil only opens SUR2B channels, though SUR1 and SUR2B are present in human hair follicles. To expand our understanding, the red deer hair follicle model was used initially. Deer follicles …
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Determining whether plasma levels of KATP channels are related to vascular function
… by measuring levels of mRNA subunits, Kir6.1/SUR2B, using real time reverse transcription polymerase chain reaction (RT-PCR) test while vascular function was assessed using (i) iontophoresis with laser Doppler flowmetry (LDF); (ii) post-occlusive reactive hyperaemia test (PORH) in the skin …
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Functional cell biology and molecular pharmacology of ATP sensitive potassium channels.
… muscle, Kir6.2 is the pore forming subunit and SUR2B is the associated regulatory subunit.A structurally diverse group of agents called K ATP channel openers (K ATP COs), have affinity for the SUR of K ATP channels, causing a hyperpolarisation of the cell membrane and a decrease in excitability. …
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The hemo-neural hypothesis : effects of vasodilation on astrocytes in mammalian neocortex
… developed a means of inducing dilation using the SUR2B receptor agonist pinacidil, which is specific to vascular smooth muscle. It was important to ascertain that pinacidil had no direct effect on astrocytes or neurons, and we confirmed this in whole cell recordings in cortical slices. We then …
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Mechanisms of pathological adipogenesis
… expressed the KATP channel subunits Kcnj8 and Sur2B, and the BK channel subunits Kcnma1 and Kcnmb2. 12 types of functional ion channels were detected in electrophysiology experiments but could not be identified. In conclusion, ghrelin treatment did not inhibit adipogenic differentiation in 7F2 …
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Osteoarthritis: the role and mechanisms of the chondroprotective peptide Urocortin I
… mRNA expression of the Kir6.1, Kir6.2, SUR1 and SUR2B subunits of the KATP channels suggesting that functional KATP channels are also present in these cells, which represent a further putative mechanism of action for UCNI. Quantitative PCR studies were performed to determine regulation of CRFR …