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Showing 1 to 11 of 11 for “"; SUR1"”.
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Investigations into the roles of potassium channels in hair growth. Studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approaches.
… component of KATP channels has three forms: SUR1, SUR2A and SUR2B which all respond to different molecules. Minoxidil only opens SUR2B channels, though SUR1 and SUR2B are present in human hair follicles. To expand our understanding, the red deer hair follicle model was used initially. Deer …
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Mechanistic investigation of coordinated conformational changes in multisubunit ion channels and enzymes
… subunit, Kir6.2 and a regulatory subunit, SUR1. Kir6.2 is an inwardly rectifying potassium channel, and SUR1 belongs to the ATP-binding cassette (ABC) superfamily. Using patch clamp techniques, KATP channel activity was observed directly with single-channel resolution. The results indicate …
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Die Rolle der 14-3-3-Proteine beim Vorwärtstransport von Kaliumkanälen
… der beiden Untereinheiten Kir6.2 und SUR1 essentiell. Vier Kanal-bildende Untereinheiten Kir6.2 müssen sich mit vier regulatorischen SUR1-Untereinheiten zu einem Oktamer zusammenlagern, damit der am Prozess der Insulinsekretion beteiligte Kaliumkanal zur Plasmamembran transportiert …
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Investigation of KATP channel function in response to metabolic and pharmacological manipulation, in the hypothalamic GT1-7 cell line
… changes observed in KATP channel activity, the SUR1-selective KATP channel opener, NN414, was applied chronically to GT1-7 cells. However, chronic KATP channel activation severely reduced channel conductance and sensitivity to activation by MgADP and further NN414 application. These results …
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Membrane trafficking of ATP-sensitive potassium channels
… of fluorescence associated with Kir6.2 and SUR1 was - 2.5 fold greater in cells incubated with 3 mM compared to 25 mM glucose. This sudden increase in channel numbers is due to an increase in the rate of translation of pre-existing mRNA and may be mediated by the activation of AMP-activated …
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ABCB6 Is a Porphyrin Transporter with a Novel Trafficking Signal That Is Conserved in Other ABC Transporters
… loss of the conserved cysteine residue in ABCC8/SUR1 is the genetic basis for hyperinsulinemic hypoglycemia. Because ER redox status appears to play an important role in the trafficking of these proteins, expression patterns of ABC transporters may be altered in pathophysiological conditions such …
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Trafficking motifs in potassium channels
… secretion. The channel subunits, Kir6.2 and SUR1, are encoded by the KCNJ11 and ABCC8 genes respectively. Genetic polymorphisms in these genes, which reduce channel activity, cause congenital hyperinsulinism (CHI) characterized by insulin hyper-secretion and hypoglycemia. The hERG (human …
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Osteoarthritis: the role and mechanisms of the chondroprotective peptide Urocortin I
… C-20/A4 mRNA expression of the Kir6.1, Kir6.2, SUR1 and SUR2B subunits of the KATP channels suggesting that functional KATP channels are also present in these cells, which represent a further putative mechanism of action for UCNI. Quantitative PCR studies were performed to determine regulation …
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Ion channel modulation during Chlamydia trachomatis development
… the canonical regulatory subunit of Kir6, SUR1/2, was never recruited to the inclusion. Correspondingly, the positive modulator of the heteromeric channel PIP2 did not colocalise with Kir6 at the inclusion. Analysis of K+ flux following siRNA-mediated knockdown of Kir6 in infected cells …
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Herstellung und Untersuchungen von polymerbasierten Wirkstofftransportsystemen
… mit bioaktiven Liganden wie Biotin, einem SUR1-Pharmacophor, zwei Streptozotocin-Derivaten und weiteren Kohlenhydraten zu funktionalisieren. Zudem konnte einer dieser Liganden auf den Oberflächen am Beispiel von Polymersomen durch die Bindung von Fluorescein-markiertem Neutravidin am …