Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 137 for “"; Opportunistic pathogen"”.
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Metabolic regulation of denitrification in the opportunistic pathogen Pseudomonas aeruginosa
… is a World Health Organization Priority 1 human pathogen and is one of the leading bacterial species implicated in nosocomial infections, posing a significant risk to immunocompromised patients due to its high level of intrinsic antimicrobial resistance and diverse metabolic physiology. …
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The molecular characterisation of the recA locus in the opportunistic pathogen Bacteroides fragilis
… fragilis is a human gut commensal and an opportunistic pathogen causing anaerobic abscesses and bacteraemias which are treated with the drug, metronidazole, a DNA damaging agent. The RecA protein is thought to be involved in the repair of metronidazole damage as well as damage caused by …
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Consequences of redox-active phenazines on the physiology of the opportunistic pathogen Pseudomonas aeruginosa
… us to a more general model of survival for the opportunistic pathogen P. aeruginosa.
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Effect of Water Chemistry, Pipe Material, Temperature and Flow on the Building Plumbing Microbiome and Opportunistic Pathogen Occurrence
… as a reservoir and conduit for the spread of opportunistic pathogens (OPs), such as Legionella pneumophila. This dissertation applied next-generation DNA sequencing tools to survey the composition of building plumbing microbiomes and assessed hypothetical factors shaping them. A challenge to …
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Impact of Flow Rate and Water Age on Opportunistic Pathogen Growth: Implications for Water Conservation, Fixture Design, and Policy
… water retention time (WRT) and sometimes opportunistic pathogens (OPs) growth. A novel experiment with replicated distal pipes operated at commonly used flow rates was designed to evaluate the effects of water age, flush frequency, flow rate, pipe diameter, water temperature, disinfectant …
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The Effects Of The Estrus Cycle On Microbiota Composition And The Opportunistic Pathogen Listeria Monocytogenes Infection Process In Murine Models
… the gastrointestinal stages of L. monocytogenes pathogenesis. Enteric pathogens such as L. monocytogenes interact directly with the host-microbiota during the gastrointestinal phase of pathogenesis. Recent research has recognized that microbiota plays a role in activating immune response and …
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The Influence of Prebiotics, Probiotics, and Exposure to an Opportunistic Pathogen on the Intestinal Microbiome of White Shrimp (Litopenaeus vannamei)
… shrimp as feed additives for 14 days, before a pathogen challenge to VP-EMS. Based on previous efforts, animals in this study were fed experimental diets for 14 days to allow ample amount of time for the prebiotic to be metabolized by health-promoting bacteria and for the probiotic spores to …
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Transcriptional Adaptation of Enterococcus faecalis within Macrophages and the Role of PerA in Virulence
… beneficial and detrimental to human health. The opportunistic pathogens residing within the gastrointestinal tract typically function as commensal members of the human microbiota. However, in certain circumstances these bacteria are able to escape the intestine and cause severe infections …
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Impacts of mucins on microbial physiology and interactions
… inhabiting the body, some of which are opportunistic pathogens, most people harbor these organisms without showing any signs of disease. The mucus that covers the wet epithelium and houses the microbiota is a prime candidate for offering protection from pathogens, yet its specific role …
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Elucidating Pseudomonas aeruginosa virulence gene regulation by the ribbon-helix-helix transcription factor AmrZ
The opportunistic pathogen <italic>Pseudomonas aeruginosa </italic> causes a myriad of infections to immunosuppressed patients, including endocarditis, microbial keratitis of the eye, pneumonia, urinary tract infections, and chronic lung infection in patients with cystic fibrosis. The underlying …
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Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix
Bacteroides fragilis is an opportunistic pathogen which can cause life threatening infections in humans and animals. The increasing incidence of antibiotic resistance by the bacterium has prompted the search for novel therapeutic targets. The idea of antivirulence over antimicrobial drug …
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Genome-wide association study of Pseudomonas aeruginosa adaptations to the cystic fibrosis lung
Pseudomonas aeruginosais an opportunistic pathogen that chronically infects the lungs of patients with cystic fibrosis. We know that these bacteria evolve within the lung environment, and have an idea of some of the changes that occur. I performed a genome-wide association study inP. …
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MOUSE MODELS OF IMMUNODEFICIENCY
… immunodeficient people is their propensity for opportunistic infections, which is also present in the murine counterpart. This necessitates a complete assessment of the inflammatory responses of the mouse models to the same infections that afflict humans. In paper I, we developed and applied a …
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Investigation into the transcriptional regulation and role in virulence of the Type VI Secretion System of <em>Serratia marcescens</em> Db10
… niche. Serratia marcescens (Sma) is an opportunistic enteric pathogen which is responsible for causing severe hospital acquired infections in vulnerable patients. The insect pathogen Sma Db10 possesses a functional T6SS which targets antibacterial effector molecules to kill competitor …
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Evaluating the Co-commensal Lifestyles of Staphylococcus aureus and Staphylococcus epidermidis
… Esp that can eradicate nasal carriage of the opportunistic pathogen, Staphylococcus aureus. We evaluated the ability of S. epidermidis and S. aureus to express serine protease and compete with one another in response to acidic pH and unsaturated free fatty acids; conditions encountered on …
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Molecular Investigations of Protein Assemblies Involved in Prokaryotic Virulence
… responsible for regulating virulence in the opportunistic pathogen Pseudomonas aeruginosa. P. aeruginosa utilizes type IV pili (T4P) to adhere to, and move along, surfaces. Assembly of T4P is powered by a dedicated cytoplasmic ATPase, PilB. The structural study of PilB from a related system …
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Characterization of the genetic diversity and antimicrobial resistance in Mannheimia haemolytica from feedlot cattle
Mannheimia haemolytica is an opportunistic pathogen in cattle and the main bacterial agent in bovine respiratory disease. Despite its economic importance, few studies have characterized the genetic diversity of M. haemolytica, particularly from feedlots. Three genotyping techniques (BOX-PCR, …
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Assessing the Presence of Antibiotic-Resistant Enterococcus in Reclaimed Water Used for Spray Irrigation
… supplies. This water potentially contains pathogenic bacteria; therefore, we evaluated the occurrence, concentration, and antimicrobial susceptibilities of Enterococcus spp.--an important opportunistic pathogen that remains a leading cause of nosocomial infections--in reclaimed water used …
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Purification and Activity of the DnaK Heat Shock Protein of the Emerging Human Pathogen Rhodococcus equi. Optimisation of methods of purifying DnaK from Rhodococcus equi, and the use of the purified protein in assays to demonstrate its activity in isolation and with other heat shock proteins
Rhodococcus equi is an important pathogen in foals between one to six months of age and is a major cause of death in in these animals. In addition, R. equi has recently emerged as a significant opportunistic pathogen in immunosuppressed humans, especially those infected with HIV. Despite the …
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Purification and Activity of the DnaK Heat Shock Protein of the Emerging Human Pathogen Rhodococcus equi. Optimisation of methods of purifying DnaK from Rhodococcus equi, and the use of the purified protein in assays to demonstrate its activity in isolation and with other heat shock proteins
Rhodococcus equi is an important pathogen in foals between one to six months of age and is a major cause of death in in these animals. In addition, R. equi has recently emerged as a significant opportunistic pathogen in immunosuppressed humans, especially those infected with HIV. Despite the …
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