Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"; Biguanides"”.
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Investigation of plant derived compounds mediating cell signalling effectson FOXO1a and AMPK
… relationships were assessed. Diguanides and biguanides were found ti induce similar responses but diguanides were much more toxic than biguanides, suggesting they may be less specific in their mechanism of action, or alternatively that they have different intramitochondrial targets.<br/>The …
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A study of column switching liquid chromatography in drug analysis.
… of the system. A column switching assay for biguanides involving an analytical mobile phase containing a high concentration of hydrophobic pairing ion was developed and validated. The steady state concentrations of proguanil and metabolites were determined in plasma and saliva, obtained from …
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Metformin as a potential therapy for malignant astrocytoma
… mechanisms utilized by metformin and other biguanides have not been fully elucidated. Methods The effects of metformin were evaluated, alone and in combination with other agents, on a panel of GBM cell cultures. Functional analysis of metformin mechanism of action was assessed through …
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Structural studies of organic crystals of pharmaceutical relevance. Correlation of crystal structure analysis with recognised non-bonded structural motifs in the organic solid state
… materials including chalcones, cryptolepines, biguanides and xanthines. These selected systems were validated using functional group and molecular analysis and correlating them to the Cambridge Structural Database. Crystallization studies are done on these selected systems as well as exploiting …
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Developing novel therapeutic agents for Acanthamoeba infection and investigating the process of encystment
… the current diamidines and slightly lower to the biguanides applied in the treatment for AK. The formulation of novel amidoamine compounds including myristoleyl-amidopropyl-dimethylamine (MOPD) and palmitoleyl-amidopropyl-dimethylamine (POPD) into contact lens solutions showed complete kill at a …
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The effect of metformin on vascular function and AMP-activated protein kinase activation in Type 2 diabetes
… this link are incompletely understood. Biguanides and thiazolidinediones are widely used in the treatment of Type 2 diabetes to improve glycaemia but the precise site, mode and extent of their actions remain uncertain. For example, in the United Kingdom Prospective Diabetes Study …
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Effect of oral hypoglycaemic agents on placental ABC transporter expression and activity
… There are two classes of OHAs used in pregnancy: biguanides (for example metformin) and sulphonylureas (for example glibenclamide, also known as glyburide). In the placenta a network of apical ATP-binding cassette (ABC) transporters facilitates the efflux of substances away from the fetus, thereby …
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The effects of herbal extracts and compounds on the glucose metabolism in Hep G2 cells
… activity (p<0.05, p<0.001), when compared to the biguanides class of oral anti-hyperglycaemic agent metformin (p<0.01). Consequently, goldenseal ethanolic extract (10 µL/mL) and berberine (10 µM) have emerged as key candidates for further research into glucose uptake using flow cytometry, the …
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N-Glycosylation profiles as a risk stratification biomarker for Type II Diabetes Mellitus and its associated factors
… were decreased compared to controls (Study III). Biguanides alone, or in combination with sulfonylurea and thiazolidinedione, did not improve glycaemic status at follow-up. Many participants using angiotensin converting enzyme inhibitors achieved desired targets for blood pressure control while …
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Glycemic control and pancreatic beta cells protective effect of a lanosteryl triterpene from Protorhus longifolia in hyperlipidemic and STZ-induced diabetic rats
… self-care and anti-diabetic drugs such as biguanides (metformin), thiazolidinediones and sulfonylureas. Metformin is currently the most commonly used antidiabetic drug. However, due to the lack of compliance to self-care recommendations and some undesirable side effects of metformin, there …
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An in-vitro study investigating current and novel antimicrobial agents as potential topical treatments for cutaneous infections caused by bacteria, fungi and Leishmania
… effective against amastigotes, whereas polymeric biguanides performed better against promastigotes. Chlorhexidine nanoparticles demonstrated no improvement in activity against the bacterial and fungal species in MIC, MBC and time-kill experiments. Against L. mexicana promastigotes and amastigotes, …
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Development and validation of a cell based model of insulin resistance and investigation into the intracellular molecular defects induced by diabetes and obesity
… between the class of insulin sensitiser known as biguanides, and DNA repair mechanisms, as an initial characterisation of molecular links between diabetes and cancer. I established that inhibiting the DNA repair enzyme ATM reduces the phosphorylation of the biguanide target, AMPK in response to …