Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “": tissue ablation"”.
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Improving the safety and efficacy of bimodal electric tissue ablation.
Introduction: Bimodal electric tissue ablation (BETA) is a new method of ablation, which combines the process of electrolysis with radiofrequency ablation (RFA) to increase the size of tissue ablations. The cathode of the electrolytic circuit is connected to the radiofrequency (RF) electrode to …
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Investigations of the Tissue Mechanical Properties and Susceptibility to Histotripsy-Induced Tissue Ablation for Intra-Abdominal Organs
… a non-thermal, non-invasive, focused ultrasound ablation method that uses acoustic cavitation to mechanically break down tissues [1-8]. Histotripsy is heavily dependent on the mechanical properties of the tissue, allowing it to mechanically ablate tissues of lower mechanical stiffness while …
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The Electrical Properties of Human Tissue for the Diagnosis and Treatment of Melanoma Skin Cancer
… cancer. First, a background about human skin tissue is presented. Then, a detailed description of melanoma along with current diagnosis techniques and treatment options are presented. In the experimental methods, the electrical properties of several types of tissue were analyzed, the purpose …
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Design and evaluation of a 2-D planar therapeutic ultrasound phased array
… several medical therapy applications including tissue ablation. Phased array transducers serve as important devices for delivering the high intensity focused ultrasound to the targeted tissue. These arrays often produce undesired secondary foci called grating lobes that can result in heating of …
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New minimally-invasive laser treatment in orthopaedics on spinal deformations and bone tumours
… in orthopaedics. With a focus on laser tissue interactions, this work covers a broad range of different applications from cw to femtosecond laser systems. Throughout this work, the emphasis was put on laser tissue interaction and the optimisation of laser parameters with regard to safety …
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A 3-Dimensional In Silico Test Bed for Radiofrequency Ablation Catheter Design Evaluation and Optimization
… treatment for AF is percutaneous catheter ablation to isolate arrhythmogenic areas from the rest of the atrium. The standard <em>in vitro</em> evaluation of ablation catheters through lesion studies is a resource intensive effort due to tissue variability and visual measurement methods, …
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Characterization and application of simultaneously spatio-temporally focused ultrafast laser pulses
… technology in the elds of micromachining, tissue ablation, and microscopy. With specically tailored pulses of light we have been able to begin investigation into lab-on-a-chip technology, which has the potential of revolutionizing the medical industry. Advances in microscopy have allowed …
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A unified model of electroporation and molecular transport
… such as gene delivery, drug delivery, and tissue ablation. In this thesis, we describe a quantitative, mechanistic model of electroporation and concomitant molecular transport that can be used for guiding and interpreting electroporation experiments and applications. The model comprises …
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Combinatorial Treatments and Technologies for Safe and Effective Targeting of Malignant Gliomas Using High-Frequency Irreversible Electroporation
… by the capacity to invade surrounding tissues beyond the visible tumor margin, intratumor heterogeneity, hypoxic core, and the presence of the blood-brain barrier (BBB) that restricts the penetration of large therapeutic agents, all pose formidable challenges for effective therapeutic …
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Finite element modeling of high frequency irreversible electroporation
… a minimally invasive, non-thermal method of soft tissue ablation that has potential to effectively treat tumors and atrial fibrillation without the severe muscular contractions that occur with monophasic pulses. The technology is relatively new, and further research is needed to understand the …
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High-Rate Histotripsy Methods for the Rapid Removal of Soft and Fibrous Tissue
Histotripsy is a non-invasive, focused ultrasound ablation modality that uses the precise control of acoustic cavitation to disintegrate tissue. Acoustic cavitation is the transient expansion of pre-existing nuclei to dimensions orders of magnitude beyond their original size due to large increases …
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Irreversible Electroporation for the Treatment of Aggressive High-Grade Glioma
… electroporation (IRE) is a new non-thermal focal tissue ablation technique that uses low-energy electric pulses to destabilize cell membranes, thus achieving tissue death. The procedure is minimally invasive and is performed through small electrodes inserted into the tissue with treatment duration …
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Improvements in Pulse Parameter Selection for Electroporation-Based Therapies
… electroporation (IRE) is a non-thermal tissue ablation modality in which electrical pulses are used to generate targeted disruption of cellular membranes. Clinically, IRE is administered by inserting one or more needles within or around a region of interest, then applying a series of …
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Irreversible Electroporation Therapy for the Treatment of Spontaneous Tumors in Cancer Patients
… destruction of cells in a targeted volume of tissue, using brief electric pulses, (~100 µs long) delivered through electrodes placed into or around the targeted region. These electric pulses destabilize the integrity of the cell membrane, resulting in the creation of nanoscale defects that …