Global ETD Search
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Showing 1 to 13 of 13 for “",hepatic stellate cell"”.
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Hepatic stellate cell heterogeneity and function during the hepatic regenerative response
… the Western world1 and results in centrilobular hepatic necrosis. In non-severe cases the liver regenerates to normal microarchitecture and function. However, in severe APAP-induced ALF, transplantation remains the only curative treatment. Hepatic stellate cells (HSCs) play a central role during …
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Physiology and Pathophysiology of Retinoid and Lipid Storage in Mouse Hepatic Stellate Cell Lipid Droplets
… and, of this fraction, 80-90% is stored in the hepatic stellate cell (HSC) lipid droplets as retinyl ester. These lipid droplets are a distinguishing feature of the HSC, and they have recently been proposed to be specialized organelles for the storage of retinoid based on their unique retinoid …
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The role of relaxin in the regulation of human liver and kidney fibrosis
… mortality is portal<br/>hypertension. The hepatic stellate cell is accepted as a major progenitor of liver<br/>myofibroblasts, which have been shown to be a major source of collagen and<br/>extracellular matrix proteins that disrupt liver architecture and function. Relaxin<br/>is a hormone …
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The role of nerve growth factor and p75 neurotrophin receptor in recovery from liver fibrosis
Rodent hepatic myofibroblasts are susceptible to nerve growth factor-mediated apoptosis through p75 neurotrophin receptor ligation. Hepatic myofibroblast apoptosis is critical to resolution of liver fibrosis. I show that human hepatic myofibroblasts exhibit differential responses to mature and …
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Aerobic exercise training as a mitigator of nonalcoholic fatty liver disease related fibrosis
… These improvements were associated with lowered hepatic stellate cell activation, a cell type in the liver that when activated begins to lay down scar tissue. Interestingly, the inactive, obese rat may actually have had the greatest capacity to turn over fibrotic tissue but this was not enough to …
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Detection and characterization of rat hepatic stellate cells in a 3-dimensional, perfused, liver bioreactor
… homeostasis require the presence of all liver cell types. In vivo experiments offer only a snapshot of the liver, and usually involve perturbation of normal function through injury or experimental disease. The role of cell-cell interactions in maintaining normal liver function is far less …
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Engineering in vitro models of non-alcoholic fatty liver disease
… (NASH), fibrosis/cirrhosis and hepatocellular carcinoma (HCC). There is no cure for NAFLD or its downstream complications and questions still remain about what factors contribute to disease progression. Specifically, the cause(s) of insulin resistance, lipid accumulation, inflammation, …
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Innate Interleukin-17 and Interleukin-22 play important roles in viral hepatitis
Intrahepatic cell-derived IL-17 and IL-22 are important for T cell priming and hepatoprotection in viral hepatitis, respectively; however, the source and regulation of these cytokines in the liver microenvironment are not well defined. Here, we present evidence for a significant expansion of IL-17- …
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Exploring the interactions between schistosome eggs and the human host
Schistosoma flatworms are a genus of parasitic blood flukes that inhabit tropical and developing communities throughout Africa, Asia and South America. Infection with Schistosoma flukes causes the disease schistosomiasis, which results in approximately 200,000 deaths per year in Sub-Saharan Africa …
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Spatially-defined quantitative interleukin 6 (IL-6) detection using polyethylene glycol microgel sensors (μGELISA)
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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Investigation of Gut-Derived Circulating Succinate in Metabolism and Liver Signaling
… acid (TCA) cycle is the epicenter of cellular aerobic metabolism and accounts for the majority of cellular ATP production. In addition to its use in anabolic and catabolic processes, TCA cycle intermediates may serve as signaling molecules. The TCA cycle intermediates succinate and …
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Effetti di Sorafenib, Imatinib e CORM-A1 in un modello pre-clinico di fibrosi epatica.
… da un eccessivo accumulo di matrice extracellulare all'interno del parenchima epatico ed è basata su complesse interazioni tra le cellule stellate epatiche di Ito responsabili della produzione di collagene e le cellule epatiche residenti. La fibrosi rappresenta una riposta intrinseca a un …