Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “", glucocerebrosidase"”.
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Potential Impacts of Pharmaceutical Uses of Transgenic Tobacco: The Case of Human Serum Albumin and Gaucher's Disease Treatment
… second paper (chapter 3) examines the case of Glucocerebrosidase Enzyme from transgenic tobacco. Results demonstrate that new products from bio-pharming applications stand to generate significant social benefits. The introduction of Human Serum Albumin generates average annual gains of $46 …
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MODELLING GBA1-RELATED PARKINSON¿S DISEASE PATHOLOGY IN PATIENT-DERIVED MIDBRAIN ORGANOIDS
… encoding the glucosylceramide-hydrolyzing enzyme glucocerebrosidase, cause Gaucher’s disease and are the most frequent genetic risk factor for Parkinson’s disease. However, a defined link between mutations in GBA1 and Parkinson’s disease pathology is yet to be determined, largely because of the …
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Gaucher Disease Protects Against Tuberculosis
Biallelic mutations in the glucocerebrosidase (GBA1) gene cause Gaucher disease, characterized by lysosomal accumulation of glucosylceramide and glucosylsphingosine in macrophages. This and other lysosomal diseases occur with high frequency in Ashkenazi Jews. It has been proposed that the …
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Genetic determinants of cognitive heterogeneity in Parkinson’s disease
… in the “on” state throughout this thesis) within glucocerebrosidase-associated PD (GBA-PD) was explored. Whilst rare (five out of 127 participants with PD), glucocerebrosidase gene (GBA) mutations contribute to widespread Lewy body (LB) pathology and are associated with a younger age of onset, …
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Exploring a Role for the Parkinson Disease-Linked GBA1 Gene in Host Responses to Infections
… the GBA1 gene, encoding a protein that confers glucocerebrosidase (GCase) activity, represent the commonest risk factor for PD development. In the present study, we sought to understand the role of murine Gba1 in microbial infection. GCase activity was found to be sex- and organ-dependent in …
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CARDIOVASCULAR AUTONOMIC IMPAIRMENT IN GBA PARKINSONIAN PATIENTS
Background: Mutations in the Beta-glucocerebrosidase (GBA) gene are the most common genetic risk factor for Parkinson’s disease (PD). GBA-associated PD (GBA-PD) has been linked to a higher prevalence of non-motor symptoms compared to idiopathic PD (I-PD), raising the question of whether autonomic …
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Three Essays on Measuring the Ex-ante Economic Impacts of Agriculture Technology Innovations
… process of a monopolist. The application to Glucocerebrosidase enzyme from transgenic tobacco suggests an intellectual property rights (IPRs) value of about $1.75 billion. Despite the innovator's market power, significant surplus gains also accrue to consumers. Further, U.S. antitrust laws …