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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 249 for “"&946"”.
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Cimento a base de β-fosfato tricálcico em defeitos ósseos produzidos no crânio de coelhos
A perda de tecido ósseo é um problema grave tanto na medicina humana quanto na veterinária. No caso das falhas ósseas cranianas, a intervenção cirúrgica se faz necessária porque, se não forem corrigidas, provocam altos índices de lesões cerebrais e disfunções neurológicas, bem como graves sequelas …
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Caracterização reológica e estrutural de géis ácidos das proteínas α-lactalbumina, β-lactoglobulina e glicomacropeptídeo
As características reológicas e morfológicas de géis de proteínas do soro acidificados com glucona-δ-lactona foram estudadas. Foi avaliado o efeito da composição proteica (concentrações de β-Lactoglobulina, α-Lactalbumina e Glicomacropeptídeo) nas propriedades de gelificação e reológicas utilizando …
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Molecular Mechanisms of Interleukin-1beta-Stimulated Regulation of Angiogenesis in Cardiac Microvascular Endothelial Cells.
<p>Angiogenesis, the formation of new vessels from a preexisting vasculature, is critical for supplying a healing myocardium with oxygen and nutrients to sustain metabolism post myocardial infarction (MI). Interleukin-1β (IL-1β), a proinflammatory cytokine increased in the heart post-MI, is …
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Incorporation of Cα,α-Disubstituted Amino Acids into Model Peptide Systems: Conformational Analysis and Possible Applications as Therapeutic Agents
A diverse set of human diseases is associated with the misfolding of proteins into insoluble fibrillar structures that have predominantly β-sheet secondary structure. Thus it is imperative to elucidate the structural elements that contribute to β-sheet formation and stability. Peptides that …
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Effects of Osmolytes on Amyloid-beta Protein Surface Activity and Membrane Interactions
The misfolding and aggregation of proteins into fibrillar aggregates in the brain are linked to the pathogenesis of over 20 neurodegenerative diseases. Specifically, the toxicity and neurodegenerative symptoms of Alzheimers disease are directly related to the aggregation of the amyloid-β (Aβ) …
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Nongenomic Effects of Estrogens on Epithelial Chloride Secretion.
<p>The human colonic cell line T84, a model for studying epithelial chloride secretion and cystic fibrosis chloride channel (CFTR) function, was used to investigate the regulatory role of estrogens in transepithelial ion transport. Estrogens and other steroid hormones do not stimulate chloride …
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Losing our lakes: an assessment of the human dimensions of lakeshore landowner shoreland management
The fragility of shorelines and the impact of residential development on habitat and water quality led to the Minnesota Department of Natural Resource's interest in promoting native vegetative buffers. First, I used the Integrative Model (IM) (Fishbein & Yzer, 2003) to evaluate lakeshore …
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New Methods for the α-Functionalization of Thioesters and Activated Hydrazones and an Application Toward the Total Synthesis of Apratoxin D
<p>Cascade reactions, also referred to as domino reactions, have been widely used for the formation of carbon-carbon bonds. This type of reaction has the potential to circumvent protection and deprotection steps, shortening an overall synthetic process.</p><p>The Morita-Baylis-Hillman (MBH) …
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The Role of DNA Methylation and Methyl Binding Domain Protein 2 in the Regulation of Human Embryonic and Fetal Beta Type Globin Genes
The genes of the human β-globin locus are located on chromosome 11 in the order of their expression during development: 5' ε, γ, β 3'. During development, silencing of the 5' gene occurs with activation of the immediate 3' gene. This process occurs twice and is termed hemoglobin switching. The …
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Mechanism of Transcriptional Regulation of C-Reactive Protein Gene Expression.
<p>C-reactive protein (CRP) is an acute phase protein produced by hepatocytes whose serum concentration increases in inflammatory conditions including cardiovascular complications. Statins that are used in the treatment of cardiovascular diseases to reduce cholesterol also lower serum CRP levels. …
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The Association Between Traumatic Brain Injury and Alzheimer's Disease: Mouse Models and Potential Mechanisms
Alzheimer's disease: AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β: Aβ) peptides, and neurofibrillary tangles: NFTs) composed of hyperphosphorylated tau proteins. Aβ is thought to act upstream of tau, …
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Isolierung, Charakterisierung und Funktionsanalyse von TGF-Beta-Signaltransduktionskomponenten des Fuchsbandwurms Echinococcus multilocularis
Die molekularen Mechanismen der Wirt-Parasit-Interaktion bei der durch den Zestoden Echinococcus multilocularis ausgelösten Erkrankung der alveolären Echinokokkose sind bislang ungeklärt. Zudem liegen keine Daten über Entwicklungs- und Differenzierungsmechanismen dieses Parasiten vor, die für die …
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Role of Sodium Arsenite in Atherogenesis
Epidemiological studies as well as controlled animal studies have associated exposure to arsenic through drinking water with the development of atherosclerosis. In this study, we have shown for the first time that low and environmentally relevant concentrations of arsenic accelerate atherogenesis. …
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Role of Sodium Arsenite in Atherogenesis
Epidemiological studies as well as controlled animal studies have associated exposure to arsenic through drinking water with the development of atherosclerosis. In this study, we have shown for the first time that low and environmentally relevant concentrations of arsenic accelerate atherogenesis. …
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Regulation of Murine Mast Cell Homeostasis by TGF-β1 and CD4+CD25+C Regulatory T Cells
Understanding mast cell development is central to allergic disease pathophysiology. Our laboratory has previously shown that cytokines such as IL-4 and IL-10 inhibit mast cell development from bone marrow progenitors. These studies encouraged our interest in other regulatory cytokines, including …
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CHARACTERIZATION OF ELECTROSPRAYED POLY(VINYLIDENE FLUORIDE)/CNT NANOCOMPOSITE
PVDF, Poly(vinylidene fluoride), is a polymer that has been studied for over four decades due to its good electromechanical properties, stability, and durability in various environments. Currently, PVDF is the only commercially available piezoelectric polymer. PVDF is a polymorph, which indicates …
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A Study of Quantum Interference and Entanglement with Negative Optics
<p>Geometrically decorated two-dimensional (2D) discrete surfaces can be more effective than conventional smooth reflectors in managing wave radiation. Constructive non‐specular wave scattering permits the scattering angle (β) to be other than twice that of incidence (α). This result in gross …
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DEVELOPMENT OF ALZHEIMER'S-LIKE PATHOLOGY IN NON-HUMAN PRIMATES WITH REDUCED LEVELS OF NOREPINEPHRINE
Synthesis of the norepinephrine distributed to sub-cortical and cortical brain regions occurs in the locus coeruleus. Impaired function results in reduced availability of norepinephrine. Locus coeruleus degeneration is a well-documented feature of Alzheimer's disease; however, the role of …
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Applications of 2,3-Diketoesters in Organic Synthesis and Stereoselective Transformations
Dimethyldioxyrane oxidation of δ-hydroxy-α-diazo-β-ketoesters that are prepared by zinc triflate catalyzed Mukaiyama-aldol condensation of methyl diazoacetoacetates with aldehydes, occurred in quantitative yield to form dihydrofuranols that undergo acid catalyzed dehydration under mild conditions …
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Intra-operative Assessment of Breast Tumor Margins Using Diffuse Reflectance Spectroscopy
<p>Breast cancer is one of the leading causes of death every year in the United States for women. Breast conserving surgery (BCS) is one treatment option for these patients where achieving tumor-free surgical margins is desired to avoid local recurrence [1, 2]. Unfortunately, as many as 17.7-72% of …
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