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Showing 1 to 20 of 183 for “""Click" Chemistry"”.
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Approaches to Asymmetric Click Chemistry
CuAAC 'click' is an invaluable synthetic tool, with asymmetric examples are beginning to emerge. However no rugged asymmetric CuAAC system has to date been discovered. This project aims to develop and utilize asymmetric CuAAC reactions in the synthesis of natural product mimicking macrocycles and …
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Click chemistry for colloidal assembly
Abstract Click chemistry has gained significant importance over the period of last decade as an efficient tool for synthetic chemistry. These set of highly efficient, high yielding and extremely resilient reactions use an approach similar to the one employed by nature, with very few by products and …
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SYNTHESIS AND CHARACTERISATION OF NOVEL BIOPOLYMERS VIA CLICK CHEMISTRY
… azide–alkyne cycloaddition, as an efficient Click reaction, for the synthesis of novel biopolymers with a broad range of potential medical/industrial applications. The strategy is to develop a powerful tool for the synthesis of libraries of materials, which will be discussed in separate …
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Functionalization of Peptide Nucleic Acids via post-synthetic click chemistry
… functionalization of PNA via post-synthetic click chemistry. Chapter 2 presents the synthesis of quencher-free PNA molecular beacons (MBs) targeting a cystic fibrosis transmembrane conductance regulator (CFTR) sequence mutation. To avoid the tedious synthesis of functionalized PNA monomers …
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Semiconductor Polymer Architectures using Click Chemistry and Controlled Radical Polymerization
Diese Dissertation beschäftigt sich mit der Synthese und Charakterisierung von halbleitenden Seitenkettenpolymeren und –blockcopolymeren für die Anwendung in organischen Photovoltaik-Bauelementen. Besonderer Augenmerk liegt dabei auf der Entwicklung und der Anwendung von modernen Synthesetechniken …
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Synthetic Strategies Towards Pi-Extended Dithienophospholes Available for Click Chemistry
… modifying the acetylene to be able to perform click chemistry saw many difficulties. An alternative route was explored where the cross-coupling reaction with a brominated bithiophene was performed first, then a ring closure reaction to form the phosphole was done. Finally, the emissive …
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Controlled metabolic cell labeling and bioorthogonal click chemistry for cancer targeting
… metabolic cell labeling and bioorthogonal Click chemistry. By controlling the metabolic glycoengineering processes of unnatural sugars via rational chemistry designs, I was able to design a library of trigger-activatable sugar precursors that can label cell surface with chemical groups …
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Development of a New General Click Chemistry and Applications in Bioconjugation: Part I: Rewiring Bacteria Cell Surfaces with Bio-Orthogonal Chemistry Part II: A Novel General Dialdehyde Click Chemistry for Primary Amine Conjugation
… groups have revolutionized the fields of chemistry, biology and material science. Due to its abundance, the primary amine is the most convenient functional group handle in molecules for ligation to other molecules for a broad range of applications that affect all scientific fields. Current …
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Investigating the size effect of nanoparticles in Click Chemistry mediated cancer targeting
… our investigation of the size effect of NPs in Click Chemistry mediated cancer targeting. Realized by anchoring NPs onto the cell surface via metabolic glycoengineering for the cell surface placement of azido group followed by Click Chemistry mediated covalent reaction between the NP and the …
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Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids
The utilization of click chemistry to perform inter- and intramolecular ligation on DNA has become ubiquitous in the literature. Advances in copper (I) stabilizing ligands that prevent DNA degradation via redox pathways have provided nucleic acid researchers access to the efficiency and …
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Click Chemistry as Efficient Ligation Strategy for Complex Macromolecular Architecture and Surface Engineering
Click-Chemie wurde als Ligations-Strategie für die Synthese von cyclischen Polymeren und zur Oberflächenmodifizierung von großen Mikrokugeln und magnetischen Eisenoxidpartikeln verwendet. Das breite Spektrum dieses universellen und leistungsstarken Instruments im Bereich der komplexen …
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Conjugation of Anti-HER2 Monoclonal Antibody onto a PLGA-PEG Nanoparticle Using CuAAC Click Chemistry
… to an anti-HER2 monoclonal antibody via click chemistry. The targeting ability of the conjugated system was analyzed via flow cytometry and fluorescent microscopy to determine its effectiveness and activity.</p> <p>Perhaps the most important pieces of information that will allow for a …
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A Pretargeted Spect Imaging Strategy Employing Technetium-99M Based on Bioorthogonal Diels-Alder Click Chemistry
… that utilizes the bioorthogonal Diels-Alder click reaction between tetrazine (Tz) and transcyclooctene (TCO). The objective was to optimize the excretory pathways of the <sup>99m</sup>Tc-peptide complexes for maximum tumor targeting with the <em>in vivo </em>“click” and minimum non-target …
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Synthesis and Evaluation of Trans-bilayer Cross Linking Phospholipids Based on Click (Azide-Alkyne) Chemistry
… with each other from the alkyl chain through click reaction to form bola-PC. Successful coupling of monomeric phosphatidylcholine derivatives would lead to synthesis of corresponding phosphatidylinositol molecules as future work. PC derivatives that were synthesized in this work were …
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A Novel Click Chemistry-Based Method to Detect Hypoxic Tumour Cells and Characterise Their Gene Expression
… and entrapment of adducts in hypoxic cells, the ‘clickable’ 2- nitromidazole hypoxia marker (SN33267) bearing a terminal alkyne group can be derivatised via copper(I)-catalysed alkyne-azide cycloaddition (CuAAC) with azides. Labelling of hypoxic cells with fluorophore azides, after exposure to …
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STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH
… reactions and products. Using this well-known click chemistry reaction, a non-steroidal anti-inflammatory drug, naproxen, could possibly be coupled to an apoptosis inhibitor, Q-VD-OPh. Two synthetic routes were envisioned. The most effective click reaction was the Cu(I) catalyzed cycloaddition …
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One click closer to understanding transglutaminase 2
Contains fulltext : 102348.pdf (Publisher’s version ) (Open Access)
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Thiol-Ene Click Chemistry for Solid State Triplet-Triplet Annihilation Upconversion and Parts-Per-Billion Pyrophosphate Sensing in Artificial Seawater
<p>Thiol-ene click chemistry is a robust approach to molecularly engineering polymers for many applications. Within this work, thiol-ene click chemistry is used to fabricate thiol-ene networks for TTA-UC and to synthesize a conjugated polyelectrolyte (CPE) used as a pyrophosphate (PPi) sensor in …
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Development of a click chemistry approach for cancer cell targeting and evaluating the effect of protein corona on active targeting yield
… approach to target NPs to the cancer cells via click chemistry. Cancer cells are first metabolically labeled with an azide-modified monosaccharide (azidosugar). In the second step, NPs that are functionalized with highly-reactive cycloalkynes selectively bind to the cancer cells due to a …
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A 'Toolkit' of Small Molecules for Polymer Assembly and Post-Synthetic Modification Using 'Click' and Photoactive Chemistries
… compounds rely upon a combination of photochemistry and the 'click' philosophy to alter the architecture, bulk properties, or surface chemistry of polymers. In Chapter 1, a review is presented that details the many implementations of the 'click' philosophy to polymer chemistry. The …
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