N-(3-Oxododecanoyl)-L-Homoserine Lactone in the Breast Tumor Microenvironment

The tumor microenvironment is a well-recognized contributor to cancer progression in solid tumors. Cancer cell interactions with abnormal extracellular matrix, tumor associated immune and stromal cells, and aberrant fluid flow all contribute to cancer progression. Breast tumors are often characterized by a dense collagenous stroma and a hypoxic core. A recently identified and little understood component of the breast tumor microenvironment is the breast microbiome. The work described here elaborates on the importance of the tumor microenvironment in cancer progression and demonstrates the importance of studying cancer-microbiome interactions in the context of tumor microenvironmental stimuli.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

masters

Discipline thesis:degree_discipline

Biomedical Engineering

Department dc:contributor.department

Biomedical Engineering

Grantor dc:publisher

Virginia Tech

Year dc:date.issued

2017

Author dc:creator

• Balhouse, Brittany Nicole

Chair dc:contributor.committeechair

• Verbridge, Scott

Committee members dc:contributor.committeemember

• Schmelz, Eva M.
• Davalos, Rafael V.
• Slade, Daniel J.

• N-(3-oxododecanoyl)-L-homoserine lactone
• breast cancer
• microbiome
• tissue engineering
• tumor microenvironment
• in vitro

Statement dc:rights

• In Copyright

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Dc Identifier Other

vt_gsexam:11306

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/78027