The metabolism of highly chlorinated naphthalenes by the albino rat and the calf

Experiments were undertaken to study, in vitro and in vivo, the metabolism or highly chlorinated. naphthalenes by the albino rat and the calf. Three studies were made. The first involved the determination of the amount of uptake of hexaehloronaphthalene by rat liver and kidney tissue. Similar studies on calf liver and kidney also were made. Secondly, balance studies were conducted, comparing the relative amounts of hexa- and octachloronaphthalene absorbed after feeding these compounds to rats. Finally, experiments were undertaken to investigate the possible formation of conjugated products as a means of chlorinated naphthalene metabolism. From the studies, a number of conclusions were derived. 1. In the rat and calf, liver seems to be an active metabolizing or detoxifying organ as evidenced by uptake of hexachloronaphthalene by liver of both these animals. Kidney on the other hand showed no uptake in either animal. Calf liver has a greater capacity tor hexachloronaphthalene uptake than does rat liver tissue.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

masters

Discipline thesis:degree_discipline

Biochemistry

Department dc:contributor.department

Biochemistry

Grantor dc:publisher

Virginia Tech

Year dc:date.issued

1955

Author dc:creator

• Joyce, Brendan E.

Chair dc:contributor.committeechair

• Pardue, Louis A.

Committee members dc:contributor.committeemember

• Johnston, G. Burke
• Engel, R. W.

Statement dc:rights

• In Copyright

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Language dc:language.iso

en

Dc Identifier Other

etd-04122010-083516

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/42024