Registration of Images with Varying Topology using Embedded Maps

In medical images, intensity changes caused by certain pathology can change the topology of image level-sets and are thus commonly referred to as topological changes. Topological changes cause false deformation in existing deformable registration algorithms, which in turn leads to unreliable observations in the clinical study that relies on the deformation fields, such as deformation based morphometry (DBM). In this work, we develop a new deformable registration algorithm for images with topological changes. In our proposed algorithm, 3D images are embedded as 4D surfaces in a Riemannian space. The registration is therefore conducted as a surface evolution, which is modeled by a diffusion process. Our algorithm differs from existing methods in the sense that it takes an a-priori estimation of areas with topological change as an additional input and generates dense deformation vector fields which are free of false deformation. In particular, the output of our algorithm is composed of a diffeomorphic deformation field and an intensity displacement which corrects intensity difference caused by topological changes. By conducting multiple sets of experiments, we demonstrate that our proposed algorithm is capable of accurately registering images with considerable topological changes. More importantly, the resulting deformation field is not impacted by topological changes, i.e., there is no false deformation.

Name thesis:degree_name

Ph. D.

Level thesis:degree_level

doctoral

Discipline thesis:degree_discipline

Electrical and Computer Engineering

Department dc:contributor.department

Electrical and Computer Engineering

Grantor dc:publisher

Virginia Tech

Year dc:date.issued

2010

Author dc:creator

• Li, Xiaoxing

Chair dc:contributor.committeechair

• Wyatt, Christopher L.

Committee members dc:contributor.committeemember

• Baumann, William T.
• Beex, A. A. Louis
• Wang, Ge
• Xuan, Jianhua Jason

• registration
• deformable
• Riemannian embedding
• topological change

Statement dc:rights

• In Copyright

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Dc Identifier Other

etd-11192010-120208

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/29683