Proof-of-Concept For Converging Beam Small Animal Irradiator

<p>The Monte Carlo particle simulator TOPAS, the multiphysics solver COMSOL., and</p> <p>several analytical radiation transport methods were employed to perform an in-depth proof-ofconcept</p> <p>for a high dose rate, high precision converging beam small animal irradiation platform.</p> <p>In the first aim of this work, a novel carbon nanotube-based compact X-ray tube optimized for</p> <p>high output and high directionality was designed and characterized. In the second aim, an</p> <p>optimization algorithm was developed to customize a collimator geometry for this unique Xray</p> <p>source to simultaneously maximize the irradiator’s intensity and precision. Then, a full</p> <p>converging beam irradiator apparatus was fit with a multitude of these X-ray tubes in a</p> <p>spherical array and designed to deliver converged dose spots to any location within a small</p> <p>animal model. This aim also included dose leakage calculations for estimation of appropriate</p> <p>external shielding. The result of this research will be the blueprints for a full preclinical</p> <p>radiation platform that pushes the boundaries of dose localization in small animal trials.</p>

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation (PhD)

Year dc:date.available

2024

Authors dc:creator

• Insley, Benjamin
• <p>0000-0002-8113-0493</p>

Contributors dc:contributor

• Mohammad Salehpour
• David Jaffray
• Dirk Bartkoski

• Small animal radiotherapy
• Preclinical research
• FLASH therapy
• Microradiotherapy
• Simulation
• Monte Carlo particle transport
• Mathematical modelling
• Finite element analysis
• X-ray tube
• Orthovoltage
• Numerical Analysis and Computation
• Numerical Analysis and Scientific Computing
• Oncology
• Ordinary Differential Equations and Applied Dynamics
• Other Physics
• Partial Differential Equations
• Radiation Medicine

Repository record dc:identifier

https://digitalcommons.library.tmc.edu/utgsbs_dissertations/1341

OAI identifier oai:identifier

oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-2398