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University of Illinois at Urbana-Champaign
Part I. The Synthesis and Study of Luminescent Polyglycerol Dendrimers. Part II. Adenine Receptors With Simultaneous Watson-Crick and Hoogsteen Binding
Abstract
dc:description"Part II discusses efforts to synthesize receptors that employ hydrogen bonds to both the Hoogsteen and Watson-Crick faces of adenine as a means of enhancing the molecular recognition of this important biomolecule. A number of design approaches were carried out to ""clamp"" the exocyclic amine group of adenine. Model studies in chloroform as well as computer modeling demonstrated that multiple contacts on each face were necessary to obtain increased affinity over Nature's chosen hydrogen-bonding partner to adenine, thymine. A promising bicyclic ligand for adenine was synthesized using this approach."
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- McKay, Jonathan
- Contributors dc:contributor
-
- Zimmerman, Steven C.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3290318
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84274